Outline of immunology

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The following outline is provided as an overview of and topical guide to immunology:

Immunology is the study of all aspects of the immune system in all organisms.[1] It deals with the physiological functioning of the immune system in states of both health and disease; malfunctions of the immune system in immunological disorders (autoimmune diseases, hypersensitivities, immune deficiency, transplant rejection); the physical, chemical and physiological characteristics of the components of the immune system in vitro, in situ, and in vivo.

Essence of immunology[edit]


Branches of immunology[edit]

History of immunology[edit]

History of immunology

General immunological concepts[edit]

  • Immunity against:

Components of the immune system[edit]

Immune system

  Adaptive immune system[edit]

Adaptive immune system

  • Kinds of Antibodies
  • Classification
  • Functions
  • Regions

  Innate immune system[edit]

Innate immune system

  • Positive
  • Negative

Organs of the immune system[edit]

Lymphatic System

  Primary Lymphoid Organs[edit]

Primary Lymphoid Organs

  Secondary Lymphoid Organs[edit]

Secondary Lymphoid Organs

Cells of the immune system[edit]

White blood cells

  Myeloid Cells[edit]

  Lymphoid Cells[edit]

Lymphoid cells


(Non-hematopoietic cells with immune functions)


Molecules of the Immune System[edit]

Immune receptors[edit]

   Antigen receptors[edit]

  • Stimulatory
  • Inhibitory
  • Accessory molecule (CD79)
  • Co-receptors
  • Accessory molecules

   Pattern recognition receptors (PRRs)[edit]

Pattern recognition receptor

  • Dectin 1 subfamily
  • DCIR subfamily
  • Class A - Trimers
  • Class B - Two transmembrane domains
  • Others
  • NLRA (A for acidic transactivating domain)
  • NLRX

   Complement receptors[edit]

Complement receptor

   Fc receptors[edit]

Fc receptor

  • Secreted Fc receptors

   Cytokine receptors[edit]

Cytokine receptor

  • Others
  • EPOR (Erythropoietin receptor) - Homodimer
  • G-CSFR (CD114) - Homodimer upon ligand binding
  • MPL (CD110, Thrombopoietin receptor) - Homodimer upon ligand binding
  • GHR (Growth hormone receptor) - Homodimer upon ligand binding
  • PRLR (Prolactin receptor)
  • Interleukin receptors
  • CX3CR1 (Fractalkine receptor)

   Natural killer cell receptors[edit]

Natural killer cell receptors

  • Activating KIRs
  • Two domains, long cytoplasmic tail
  • Two domains, short cytoplasmic tail
  • Three domains, long cytoplasmic tail
  • Three domains, short cytoplasmic tail






  • CX3CL1 (Fractalkine, Neurotactin)


Major histocompatibility complex

Complement proteins[edit]

  • Early stage (divided by pathway)
  • Middle stage
  • Late stage
  • Complement pathway inhibitors

Antimicrobial peptides[edit]

Antimicrobial peptides

Transcription factors[edit]

  • T-bet - TH1 differentiation
  • GATA3 - TH2 differentiation
  • RORγT - TH17 differentiation
  • BCL6 - TFH differentiation
  • FoxP3 - Treg differentiation

Signaling pathways[edit]

Cell adhesion molecules (CAMs)[edit]

Cell adhesion molecules

  • Alpha subunits
  • Beta subunits
  • Dimers
  • Cytoadhesin receptor
  • Leukocyte-adhesion receptor:
  • Very late antigen receptor:
  • Others


  • CD28 - Expressed by T Cells
  • CD278 (ICOS) - Homodimer, expressed by T Cells
  • CTLA-4 (CD152)
  • PD-1 (CD279)

Immune system disorders[edit]

Immune disorder

Hypersensitivity and Allergy[edit]

  • Foreign
  • Autoimmune
  • Foreign
  • Autoimmune
  • Foreign
  • Autoimmune
  • GVHD (Graft-versus-host disease)
  • Unknown/Multiple types
  • Foreign
  • Autoimmune



Cancers of the immune system[edit]

Myeloid diseases[edit]

Inflammatory diseases[edit]

Immunoproliferative immunoglobulin disorders[edit]

Immunoproliferative immunoglobulin disorders

Lymphatic organ disease[edit]

Immunologic techniques and tests[edit]

Immunology and Health[edit]


List of immunologists

Immunology lists[edit]


  1. ^ Janeway's Immunobiology textbook Searchable free online version at the National Center for Biotechnology Information
  2. ^ http://www.genenames.org/genefamilies/CLEC. Retrieved 6 March 2014.  Missing or empty |title= (help)
  3. ^ Geijtenbeek TB, Gringhuis SI (July 2009). "Signalling through C-type lectin receptors: shaping immune responses". Nat. Rev. Immunol. 9 (7): 465–79. PMID 19521399. doi:10.1038/nri2569. 
  4. ^ Royet J, Gupta D, Dziarski R (December 2011). "Peptidoglycan recognition proteins: modulators of the microbiome and inflammation". Nat. Rev. Immunol. 11 (12): 837–51. PMID 22076558. doi:10.1038/nri3089. 

External links[edit]