Ovandrotone albumin

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Ovandrotone albumin
Combination of
OvandrotoneAndrostane steroid
Human serum albuminSerum protein
Clinical data
Trade namesFecundin, Ovastim
SynonymsPolyandroalbumin; GR-33207; Ovandrotone:human serum albumin conjugate
AHFS/Drugs.comMonograph
Pregnancy
category
  • US: X (Contraindicated)
Legal status
Legal status
Identifiers
ChemSpider
  • None

Ovandrotone albumin (INN, BAN) (brand names Fecundin, Ovastim),[1] also known as polyandroalbumin, as well as ovandrotone:human serum albumin conjugate, is an immunogen and vaccine against androstenedione that is used in veterinary medicine to increase the ovulation rate and number of lambs born to ewes.[2][3][4][5] It is a conjugate of ovandrotone (androstenedione-7α-carboxyethylthioether)[6] and human serum albumin.[5] The drug was developed by 1981 and was introduced in Australia and New Zealand in 1983.[4][7]

Ovandrotone albumin produces transient immunity against androstenedione,[8] and the generation of antibodies against androstenedione presumably decreases circulating levels of androstenedione.[7] This is thought to result in reduced negative feedback on the hypothalamic-pituitary-gonadal axis and increased gonadotropin secretion, which in turn improves fertility and fecundity.[4] Indeed, ovandrotone albumin has been found to significantly increase luteinizing hormone levels throughout the estrous cycle in ewes.[4]

See also[edit]

References[edit]

  1. ^ R. Sylvester-Bradley; Julian Wiseman (1 January 2005). Yields of Farmed Species: Constraints and Opportunities in the 21st Century. Nottingham University Press. p. 55. ISBN 978-1-904761-23-5.
  2. ^ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. p. 908. ISBN 978-1-4757-2085-3.
  3. ^ Hoskinson, R. M.; Scaramuzzi, R. J.; Campbell, B. K.; Downing, J. A.; Welch, R. J.; Harrison, B. E. (1986). "Effects of Antibodies to Steroid Hormones on Reproductive Events of Sheep and Cattle": 351–366. doi:10.1007/978-1-4684-5140-5_38.
  4. ^ a b c d Carnegie, Patrick R. (1988). "Autoimmunization Against Hormones: A New Strategy in Animal Production": 245–254. doi:10.1007/978-1-4612-3734-1_15.
  5. ^ a b International Nonproprietary Names (INN) for biological and biotechnological substances
  6. ^ Journal of Animal Science. American Society of Animal Science. 1991. pp. 3931–3932.
  7. ^ a b J.M. Sreenan; M.G. Diskin (6 December 2012). Embryonic Mortality in Farm Animals. Springer Science & Business Media. pp. 172–. ISBN 978-94-009-5038-2.
  8. ^ Lindsay, D. R., & Pearce, D. T. (Eds.). (1984). Reproduction in Sheep. Cambridge University Press.