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Oxadiazoles are a class of heterocyclic aromatic chemical compound of the azole family; with the molecular formula C2H2N2O. There are four isomers of oxadiazole:

1,2,4-Oxadiazole, 1,2,5-oxadiazole, and 1,3,4-oxadiazole are all known and appear in a variety of pharmaceutical drugs including raltegravir, butalamine, fasiplon, oxolamine, and pleconaril. The 1,2,3-isomer is unstable and ring-opens to form the diazoketone tautomer,[1] however it does exist within the unusual sydnone motif.


  1. ^ John A. Joule; Keith Mills (28 May 2013). Heterocyclic Chemistry. John Wiley & Sons. p. 842. ISBN 1-118-68164-9.