Oxalosuccinic acid

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Oxalosuccinic acid
IUPAC name
1-Oxopropane-1,2,3-tricarboxylic acid
1948-82-9 YesY
ChemSpider 947 N
ECHA InfoCard 100.230.021
Jmol 3D model Interactive image
KEGG C05379 N
PubChem 972
Molar mass 190.108
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Oxalosuccinic acid is a substrate of the citric acid cycle. It is acted upon by isocitrate dehydrogenase. Salts and esters of oxalosuccinic acid are known as oxalosuccinates.

Oxalosuccinic acid/oxalosuccinate is an unstable 6-carbon intermediate in the tricarboxylic acid cycle. It's an alpha-keto compound, formed during the oxidative decarboxylation of isocitrate to alpha-ketoglutarate, which is catalyzed by the enzyme isocitrate dehydrogenase. Oxalosuccinate never leaves the active site of the enzyme, however it's unstable and immediately undergoes decarboxylation to produce the 5-carbon compound, alpha-ketoglutarate.