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Oxathiapiprolin skeletal.svg
Preferred IUPAC name
3D model (JSmol)
ECHA InfoCard 100.227.885 Edit this at Wikidata
  • InChI=1S/C24H22F5N5O2S/c1-13-9-20(24(27,28)29)31-34(13)11-21(35)33-7-5-14(6-8-33)23-30-18(12-37-23)17-10-19(36-32-17)22-15(25)3-2-4-16(22)26/h2-4,9,12,14,19H,5-8,10-11H2,1H3
  • CC1=CC(=NN1CC(=O)N2CCC(CC2)C3=NC(=CS3)C4=NOC(C4)C5=C(C=CC=C5F)F)C(F)(F)F
Molar mass 539.53 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Oxathiapiprolin (trade names Orondis,[1] Zorvec, and Segovis) is a fungicide. In the United States, the Environmental Protection Agency has approved it for use against several fungal diseases including downy mildew and various Phytophthora species[1] including late blight on crops including vegetables, ornamentals, and turf.[2]

Its mechanism of action involves binding to the oxysterol-binding protein in Oomycetes.[3][4]


  1. ^ a b "Orondis - Fungicide Product & Label Information". Syngenta US. Retrieved 2021-03-24.
  2. ^ "Oxathiapiprolin" (PDF). New Active Ingredient Review. Minnesota Department of Agriculture. October 2015. Archived from the original (PDF) on 2017-11-07. Retrieved 2017-11-03.
  3. ^ Cohen, Yigal (2015). "The Novel Oomycide Oxathiapiprolin Inhibits All Stages in the Asexual Life Cycle of Pseudoperonospora cubensis - Causal Agent of Cucurbit Downy Mildew". PLOS ONE. 10 (10): e0140015. Bibcode:2015PLoSO..1040015C. doi:10.1371/journal.pone.0140015. PMC 4599937. PMID 26452052.
  4. ^ Pasteris, Robert J; Hanagan, Mary Ann; Bisaha, John J; Finkelstein, Bruce L; Hoffman, Lisa E; Gregory, Vann; Shepherd, Christopher P; Andreassi, John L; Sweigard, James A; Klyashchitsky, Boris A; Henry, Yewande T; Berger, Richard A (2015). "The Discovery of Oxathiapiprolin: A New, Highly-Active Oomycete Fungicide with a Novel Site of Action". Discovery and Synthesis of Crop Protection Products. ACS Symposium Series. Vol. 1204. p. 149. doi:10.1021/bk-2015-1204.ch011. ISBN 978-0-8412-3102-3.