Oxidative deamination

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Oxidative deamination is a form of deamination that generates oxoacids in the liver. This takes place in liver and kidney. The purpose of oxidative deamination is to provide NH3 for urea synthesis and alpha-keto acids for a variety of reactions, including energy generation.

The presence of nitrous acid can cause transition mutations, by converting cytosine to uracil. Oxidative deamination occurs primarily in the liver and kidneys.[1][2]

In urea cycle[edit]

Glutamate is the only amino acid that undergoes rapid oxidative deamination by using glutamate dehydrogenase, which uses NAD or NADP as a coenzyme. This process leads to two distinct toxic compounds:

See also[edit]


  1. ^ Mutations & Mutagenesis
  2. ^ Molecules and cancer

External links[edit]