Oxidative deamination

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Oxidative deamination is a form of deamination that generates oxoacids in the liver.

The presence of nitrous acid can cause transition mutations, by converting cytosine to uracil. Oxidative deamination occurs primarily in the liver and kidneys.[1][2]

In Urea cycle[edit]

Glutamate is the only amino acid that undergoes rapid oxidative deamination by using glutamate dehydrogenase, which uses NAD or NADP as a coenzyme. This process leads to two distinct toxic compounds:

See also[edit]


  1. ^ Mutations & Mutagenesis
  2. ^ Molecules and cancer

External links[edit]