Oxolinic acid

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Oxolinic acid
Oxolinic Acid Structural Formulae V.svg
Clinical data
AHFS/Drugs.com International Drug Names
ATC code
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CAS Number
PubChem CID
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UNII
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ChEBI
ChEMBL
ECHA InfoCard 100.035.213 Edit this at Wikidata
Chemical and physical data
Formula C13H11NO5
Molar mass 261.23 g/mol
3D model (JSmol)
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Oxolinic acid is a quinolone antibiotic developed in Japan in the 1970s.[1][2] Dosages 12–20 mg/kg orally administered for five to ten days. The antibiotic works by inhibiting the enzyme DNA gyrase. It also acts as a dopamine reuptake inhibitor and has stimulant effects in mice.[3]

See also[edit]

References[edit]

  1. ^ JP Patent 49138244
  2. ^ Gleckman R, Alvarez S, Joubert DW, Matthews SJ (August 1979). "Drug therapy reviews: oxolinic acid". American Journal of Hospital Pharmacy. 36 (8): 1077–9. PMID 384788. 
  3. ^ Garcia de Mateos-Verchere J, Vaugeois JM, Naudin B, Costentin J (December 1998). "Behavioural and neurochemical evidence that the antimicrobial agent oxolinic acid is a dopamine uptake inhibitor". European Neuropsychopharmacology. 8 (4): 255–9. doi:10.1016/S0924-977X(97)00083-7. PMID 9928913.