Oxyfedrine

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Oxyfedrine
Oxyfedrine2.png
Systematic (IUPAC) name
(RS)-3-[(2-Hydroxy-1-methyl-2-phenylethyl)amino]-1-(3-methoxyphenyl)propan-1-one
Clinical data
AHFS/Drugs.com International Drug Names
Identifiers
CAS Registry Number 15687-41-9 YesY
ATC code C01DX03
PubChem CID: 27454
UNII DWL616XF1K YesY
KEGG D08321 YesY
Chemical data
Formula C19H23NO3
Molecular mass 313.39 g/mol
 YesY (what is this?)  (verify)

Oxyfedrine is a vasodilator. Oxyfedrine was found to depress the tonicity of coronary vessels, improve myocardial metabolism (so that heart can sustain hypoxia better) and also exert a positive chronotropic and inotrophic effects, thereby not precipitating angina pectoris. The latter property (positive chronotropic and inotrophic effects) is particularly important, because other vasodilators used in angina may be counter productive causing coronary steal phenomenon.

Synergestic effects with antibiotics have been suggested.[1]

References[edit]

  1. ^ Mazumdar, Kaushiki; Dutta, Noton Kumar; Kumar, Kuppusamy Asok; Dastidar, Sujata Ghosh (April 2005). "In vitro and in vivo synergism between tetracycline and the cardiovascular agent oxyfedrine HCl against common bacterial strains". Biol. Pharm. Bull. 28 (4): 713–7. doi:10.1248/bpb.28.713. PMID 15802815.