oxygenase is any enzyme that oxidizes a substrate by transferring the oxygen from molecular oxygen O 2 (as in air) to it. The oxygenases form a class of oxidoreductases; their EC number is EC 1.13 or EC 1.14.
Discoverers [ edit ]
Oxygenases were discovered in 1955 simultaneously by two groups,
Osamu Hayaishi from Japan [1 ] [2 ] and Howard S. Mason from the US. [3 ] [4 ] Hayaishi was awarded the 1986 [5 ] Wolf Prize in Medicine "for the discovery of the oxygenase enzymes and elucidation of their structure and biological importance." [6 ]
Chemical Makeup [ edit ]
Oxygenases consist of both
constitutive and inducible isozymes (HO-1, HO-2). These constitute a major intracellular source of iron and carbon monoxide [7 ]
There are two types of oxygenases:
Among the most important monooxygenases are the
cytochrome P450 oxidases, responsible for breaking down numerous chemicals in the body.
References [ edit ]
^ Hayaishi et al. (1955) Mechanism of the pyrocatechase reaction, J. Am. Chem. Soc. 77 (1955) 5450-5451
^ Sligar SG, Makris TM, Denisov IG (2005). "Thirty years of microbial P450 monooxygenase research: peroxo-heme intermediates--the central bus station in heme oxygenase catalysis". Biochem. Biophys. Res. Commun. 338 (1): 346–54. doi: 10.1016/j.bbrc.2005.08.094. PMID 16139790.
^ Hayaishi O (2005). "An odyssey with oxygen". Biochem. Biophys. Res. Commun. 338 (1): 2–6. doi: 10.1016/j.bbrc.2005.09.019. PMID 16185652.
^ Mason HS, Fowlks WK, and Peterson E. (1955) Oxygen transfer and electron transport by the phenolase complex. J. Am. Chem. Soc.; 77(10) pp 2914 - 2915
^ Waterman MR (2005). "Professor Howard Mason and oxygen activation". Biochem. Biophys. Res. Commun. 338 (1): 7–11. doi: 10.1016/j.bbrc.2005.08.120. PMID 16153596.
^ "The Medicine Prize Committee unanimously decided that the Wolf Prize in Medicine for 1986 be awarded to Osamu Hayaishi". Wolf Foundation . Retrieved . May 12, 2014
^ SW, Ryter; J, Alam (April 2006). "Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications.". Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, The University of Pittsburgh School of Medicine . Retrieved . 15 December 2015
^ Bugg TDH (2003). "Dioxygenase enzymes: catalytic mechanisms and chemical models". Tetrahedron 59 (36): 7075–7101. doi: 10.1016/S0040-4020(03)00944-X.