Oxysterols are oxidized derivatives of cholesterol which may be important in many biological processes, including:
- Cholesterol homeostasis
- Sphingolipid metabolism
- Platelet aggregation
- Protein prenylation
It is currently thought that oxysterols may play an important role in atherosclerosis progression: they are likely to promote the synthesis of an extracellular matrix scaffold - via pericyte-like cells in blood vessels - which would be needed for the calcification process (deposition of Ca-phosphate crystals).
- Schroepfer, Gj, Jr (Jan 2000). "Oxysterols: modulators of cholesterol metabolism and other processes" (Free full text). Physiological reviews. 80 (1): 361–554. ISSN 0031-9333. PMID 10617772.
- Björkhem, I (Sep 2002). "Do oxysterols control cholesterol homeostasis?". The Journal of Clinical Investigation. 110 (6): 725–30. PMC . PMID 12235099. doi:10.1172/JCI16388.
- Ingemar Björkhem; Ulf Diczfalusy (2002). "Oxysterols: Friends, Foes, or Just Fellow Passengers?". Arteriosclerosis, Thrombosis, and Vascular Biology. 22 (5): 734–42. PMID 12006384. doi:10.1161/01.ATV.0000013312.32196.49.
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