P/D1 cell

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Cells lining the fundus of the human stomach that produce ghrelin. Removal of these cells in gastric bypass surgery has a profound impact on later appetite regulation.[1] These cells have also been shown to produce ghrelin's antagonistic hormone leptin.[2]


  1. ^ Inui A, Asakawa A, Bowers CY, et al. (2004). "Ghrelin, appetite, and gastric motility: the emerging role of the stomach as an endocrine organ". FASEB J. 18 (3): 439–56. doi:10.1096/fj.03-0641rev. PMID 15003990. 
  2. ^ Bado A, Levasseur S, Attoub S, Kermorgant S, Laigneau JP, Bortoluzzi MN, Moizo L, Lehy T, Guerre-Millo M, Le Marchand-Brustel Y, Lewin MJ (August 1998). "The stomach is a source of leptin". Nature 394 (6695): 790–793. doi:10.1038/29547. PMID 9723619.