P1-derived artificial chromosome

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The P1-derived artificial chromosome are DNA constructs that are derived from the DNA of P1 bacteriophage. They can carry large amounts (about 100–300 kilobases) of other sequences for a variety of bioengineering purposes. It is one type of vector used to clone DNA fragments (100- to 300-kb insert size; average, 150 kb) in Escherichia coli cells.

P1 was developed as a cloning vector by Nat Sternberg and colleagues in the 1990s.[1][2]

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