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p21 activated kinases (PAKs) are members of a family of enzymes. They serve as targets for the small GTP binding proteins CDC42 and Rac and have been implicated in a wide range of biological activities.
- PAK1, regulating cell motility and morphology
- PAK2, possibly playing a role in apoptosis
- PAK3, possibly for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity
- PAK4, a mediator of filopodia formation
- PAK5, a mediator of filopodia formation
- PAK6, involved in cytoskeleton rearrangement
- p21-Activated Kinases at the US National Library of Medicine Medical Subject Headings (MeSH)
- "Entrez Gene: PAK1 p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)".
- "Entrez Gene: PAK2 p21 (CDKN1A)-activated kinase 2".
- "Entrez Gene: PAK3 p21 (CDKN1A)-activated kinase 3".
- "Entrez Gene: PAK4 p21(CDKN1A)-activated kinase 4".
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