P2RX1

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P2RX1
Identifiers
Aliases P2RX1, P2X1, purinergic receptor P2X 1
External IDs MGI: 1098235 HomoloGene: 1921 GeneCards: 5023
RNA expression pattern
PBB GE P2RX1 210401 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002558

NM_008771

RefSeq (protein)

NP_002549.1

NP_032797.3

Location (UCSC) Chr 17: 3.9 – 3.92 Mb Chr 11: 73 – 73.02 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

P2X purinoceptor 1 is a protein that in humans is encoded by the P2RX1 gene.[1]

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with relatively high calcium permeability. Expressed in smooth muscle and platelets. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle, being responsible, for example, for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. It is possible that the development of selective antagonists for this receptor may provide an effective non-hormonal male contraceptive pill.[2]

See also[edit]

References[edit]

  1. ^ Valera S, Talabot F, Evans RJ, Gos A, Antonarakis SE, Morris MA, Buell GN (Nov 1996). "Characterization and chromosomal localization of a human P2X receptor from the urinary bladder". Receptors Channels 3 (4): 283–9. PMID 8834001. 
  2. ^ "Entrez Gene: P2RX1 purinergic receptor P2X, ligand-gated ion channel, 1". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.