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Purinergic receptor P2X, ligand-gated ion channel, 3
Symbols P2RX3 ; P2X3
External IDs OMIM600843 MGI1097160 HomoloGene1922 IUPHAR: 480 ChEMBL: 2998 GeneCards: P2RX3 Gene
Species Human Mouse
Entrez 5024 228139
Ensembl ENSG00000109991 ENSMUSG00000027071
UniProt P56373 Q3UR32
RefSeq (mRNA) NM_002559 NM_145526
RefSeq (protein) NP_002550 NP_663501
Location (UCSC) Chr 11:
57.11 – 57.14 Mb
Chr 2:
85 – 85.04 Mb
PubMed search [1] [2]

P2X purinoceptor 3 is a protein that in humans is encoded by the P2RX3 gene.[1][2]

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is important for peripheral pain responses, and also participates in pathways controlling urinary bladder volume reflexes, platelet aggregation, macrophage activation, apoptosis and neuronal–glial interactions. It is possible that the development of selective antagonists for this receptor may have a therapeutic potential in pain relief and in the treatment of disorders of urine storage.[2]

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  1. ^ Garcia-Guzman M, Stuhmer W, Soto F (Sep 1997). "Molecular characterization and pharmacological properties of the human P2X3 purinoceptor". Brain Res Mol Brain Res 47 (1–2): 59–66. doi:10.1016/S0169-328X(97)00036-3. PMID 9221902. 
  2. ^ a b "Entrez Gene: P2RX3 purinergic receptor P2X, ligand-gated ion channel, 3". 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.