P2RX3

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P2RX3
5svq.jpg
Identifiers
AliasesP2RX3, P2X3, purinergic receptor P2X 3
External IDsMGI: 1097160 HomoloGene: 1922 GeneCards: P2RX3
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for P2RX3
Genomic location for P2RX3
Band11q12.1Start57,338,374 bp[1]
End57,370,600 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002559

NM_145526

RefSeq (protein)

NP_002550

NP_663501

Location (UCSC)Chr 11: 57.34 – 57.37 MbChr 2: 85 – 85.04 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

P2X purinoceptor 3 is a protein that in humans is encoded by the P2RX3 gene.[5][6]

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is important for peripheral pain responses, and also participates in pathways controlling urinary bladder volume reflexes, platelet aggregation, macrophage activation, apoptosis and neuronal–glial interactions. It is possible that the development of selective antagonists for this receptor may have a therapeutic potential in pain relief and in the treatment of disorders of urine storage.[6]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000109991 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027071 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Garcia-Guzman M, Stuhmer W, Soto F (Sep 1997). "Molecular characterization and pharmacological properties of the human P2X3 purinoceptor". Brain Res Mol Brain Res. 47 (1–2): 59–66. doi:10.1016/S0169-328X(97)00036-3. PMID 9221902.
  6. ^ a b "Entrez Gene: P2RX3 purinergic receptor P2X, ligand-gated ion channel, 3".

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.