P2RY1

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P2RY1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases P2RY1, P2Y1, purinergic receptor P2Y1
External IDs MGI: 105049 HomoloGene: 1926 GeneCards: 5028
RNA expression pattern
PBB GE P2RY1 207455 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002563

NM_001282016
NM_008772

RefSeq (protein)

NP_002554.1

NP_001268945.1
NP_032798.1

Location (UCSC) Chr 3: 152.83 – 152.84 Mb Chr 3: 61 – 61.01 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

P2Y purinoceptor 1 is a protein that in humans is encoded by the P2RY1 gene.[1]

Function[edit]

The product of this gene, P2Y1 belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.[2]

See also[edit]

References[edit]

  1. ^ Ayyanathan K, Webbs TE, Sandhu AK, Athwal RS, Barnard EA, Kunapuli SP (January 1996). "Cloning and chromosomal localization of the human P2Y1 purinoceptor". Biochemical and Biophysical Research Communications 218 (3): 783–8. doi:10.1006/bbrc.1996.0139. PMID 8579591. 
  2. ^ "Entrez Gene: P2RY1 purinergic receptor P2Y, G-protein coupled, 1". 

Further reading[edit]

External links[edit]

  • "P2Y Receptors: P2Y1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.