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Purinergic receptor P2Y, G-protein coupled, 2
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols P2RY2 ; HP2U; P2RU1; P2U; P2U1; P2UR; P2Y2; P2Y2R
External IDs OMIM600041 MGI105107 HomoloGene1927 IUPHAR: 324 ChEMBL: 4398 GeneCards: P2RY2 Gene
RNA expression pattern
PBB GE P2RY2 206277 at tn.png
More reference expression data
Species Human Mouse
Entrez 5029 18442
Ensembl ENSG00000175591 ENSMUSG00000032860
UniProt P41231 P35383
RefSeq (mRNA) NM_002564 NM_001302346
RefSeq (protein) NP_002555 NP_001289275
Location (UCSC) Chr 11:
73.22 – 73.24 Mb
Chr 7:
101 – 101.01 Mb
PubMed search [1] [2]

P2Y purinoceptor 2 is a protein that in humans is encoded by the P2RY2 gene.[1][2]

The product of this gene, P2Y2 belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to both adenosine and uridine nucleotides. It may participate in control of the cell cycle of endometrial carcinoma cells. Three transcript variants encoding the same protein have been identified for this gene.[3]

See also[edit]


  1. ^ Parr CE, Sullivan DM, Paradiso AM, Lazarowski ER, Burch LH, Olsen JC, Erb L, Weisman GA, Boucher RC, Turner JT (May 1994). "Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy". Proc Natl Acad Sci USA 91 (8): 3275–9. doi:10.1073/pnas.91.8.3275. PMC 43559. PMID 8159738. 
  2. ^ Somers GR, Hammet F, Woollatt E, Richards RI, Southey MC, Venter DJ (Nov 1997). "Chromosomal localization of the human P2y6 purinoceptor gene and phylogenetic analysis of the P2y purinoceptor family". Genomics 44 (1): 127–30. doi:10.1006/geno.1997.4841. PMID 9286708. 
  3. ^ "Entrez Gene: P2RY2 purinergic receptor P2Y, G-protein coupled, 2". 

External links[edit]

  • "P2Y Receptors: P2Y2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.