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P45 may refer to:
- P45 (tax), a basic code for Details of employees leaving work in UK and Irish taxation
- Papyrus 45, a New Testament manuscript and part of the Chester Beatty Collection
- Pneumonoultramicroscopicsilicovolcanoconiosis, a long word in English that has 45 letters, referred to as P45
- Intel P45, a motherboard chipset by Intel Corporation
- P45, a Latvian state regional road – see List of National Roads in Latvia
- P45, a car made by Jeremy Clarkson for the motoring show Top Gear
- P45, a camera model manufactured by Phase One
- Bell P-45, the original designation of the Bell P-39 Airacobra
- Ferrari P4/5 by Pininfarina, a one-off sports car
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