P53 p63 p73 family
It consists of:
They are sometimes considered part of a "p53 family".
Evolution of the p53 family
P53, p63, and p73 have similar features in their gene structures and functions but have also diverged evolutionarily. The p53 family evolved from a p63/p73 ancestor gene in invertebrates. P53 diverged from p63/p73 with a gene duplication in the cartilaginous fish. P63 and p73 differentiated from each other in bony fish. These genes developed different functions and structures throughout their evolutionary divergence (TP73L, p73, p53) .
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- Caleb Ellicott Finch (2007). The biology of human longevity: inflammation, nutrition, and aging in the evolution of lifespans. Academic Press. pp. 350–. ISBN 978-0-12-373657-4. Retrieved 23 December 2010.
- Chen S, Moroi Y, Urabe K et al. (July 2008). "Differential expression of two new members of the p53 family, p63 and p73, in extramammary Paget's disease". Clin. Exp. Dermatol. 33 (5): 634–40. doi:10.1111/j.1365-2230.2008.02851.x. PMID 18627398.
- Levine, A. J., V. A. Belyi, P. Ak, E. Markert, H. J. Wang, W. W. Hu, and A. Puzio-Kuter. (2010). "The origins and evolution of the p53 family of genes". Cold Spring Harbor Perspectives in Biology 2.