P53 p63 p73 family

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P53 family[edit]

The p53 p63 p73 family is a family of tumor suppressor genes.[1][2]

It consists of:

They are sometimes considered part of a "p53 family".[3]

Evolution of the p53 family[edit]

P53, p63, and p73 have similar features in their gene structures and functions but have also diverged evolutionarily. The p53 family evolved from a p63/p73 ancestor gene in invertebrates.[4] P53 diverged from p63/p73 with a gene duplication in the cartilaginous fish.[4] P63 and p73 differentiated from each other in bony fish.[4] These genes developed different functions and structures throughout their evolutionary divergence (TP73L, p73, p53) .


  1. ^ Levrero M, De Laurenzi V, Costanzo A, Gong J, Wang JY, Melino G (May 2000). "The p53/p63/p73 family of transcription factors: overlapping and distinct functions". J. Cell. Sci. 113 (10): 1661–70. PMID 10769197. 
  2. ^ Caleb Ellicott Finch (2007). The biology of human longevity: inflammation, nutrition, and aging in the evolution of lifespans. Academic Press. pp. 350–. ISBN 978-0-12-373657-4. Retrieved 23 December 2010. 
  3. ^ Chen S, Moroi Y, Urabe K et al. (July 2008). "Differential expression of two new members of the p53 family, p63 and p73, in extramammary Paget's disease". Clin. Exp. Dermatol. 33 (5): 634–40. doi:10.1111/j.1365-2230.2008.02851.x. PMID 18627398. 
  4. ^ a b c Levine, A. J., V. A. Belyi, P. Ak, E. Markert, H. J. Wang, W. W. Hu, and A. Puzio-Kuter. (2010). "The origins and evolution of the p53 family of genes". Cold Spring Harbor Perspectives in Biology 2.