PA2G4

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PA2G4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPA2G4, EBP1, HG4-1, p38-2G4, proliferation-associated 2G4
External IDsMGI: 894684 HomoloGene: 4513 GeneCards: PA2G4
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for PA2G4
Genomic location for PA2G4
Band12q13.2Start56,104,319 bp[1]
End56,113,907 bp[1]
RNA expression pattern
PBB GE PA2G4 214794 at fs.png

PBB GE PA2G4 208676 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006191

NM_011119

RefSeq (protein)

NP_006182

NP_035249

Location (UCSC)Chr 12: 56.1 – 56.11 MbChr 10: 128.56 – 128.57 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Proliferation-associated protein 2G4 (PA2G4) also known as ErbB3-binding protein 1 (EBP1) is a protein that in humans is encoded by the PA2G4 gene.[5]

Function[edit]

This gene encodes an RNA-binding protein that is involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals. This protein is also a transcriptional corepressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases. This protein has been implicated in growth inhibition and the induction of differentiation of human cancer cells. Paradoxically, the expression of EBP1 is decreased in prostate cancer [6], but increased in Acute Myelogneous Leukemia.[7] Six pseudogenes, located on chromosomes 3, 6, 9, 18, 20 and X, have been identified.[8]

Interactions[edit]

PA2G4 has been shown to interact with ERBB3,[9][10] retinoblastoma protein,[11] and androgen receptor.[12]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000170515 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025364 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Lamartine J, Seri M, Cinti R, Heitzmann F, Creaven M, Radomski N, Jost E, Lenoir GM, Romeo G, Sylla BS (November 1997). "Molecular cloning and mapping of a human cDNA (PA2G4) that encodes a protein highly homologous to the mouse cell cycle protein p38-2G4". Cytogenetics and Cell Genetics. 78 (1): 31–5. doi:10.1159/000134621. PMID 9345902.
  6. ^ Zhang Y, Linn D, Liu Z, Melamed J, Tavora F, Young CY, Burger AM, Hamburger AW (October 2008). "EBP1, an ErbB3-binding protein, is decreased in prostate cancer and implicated in hormone resistance". Molecular Cancer Therapeutics. 7 (10): 3176–86. doi:10.1158/1535-7163.MCT-08-0526. PMID 18852121.
  7. ^ Nguyen le XT, Zhu L, Lee Y, Ta L, Mitchell BS (July 2016). "Expression and Role of the ErbB3-Binding Protein 1 in Acute Myelogenous Leukemic Cells". Clinical Cancer Research. 22 (13): 3320–7. doi:10.1158/1078-0432.CCR-15-2282. PMID 26813358.
  8. ^ "Entrez Gene: PA2G4 proliferation-associated 2G4, 38kDa".
  9. ^ Lessor TJ, Hamburger AW (April 2001). "Regulation of the ErbB3 binding protein Ebp1 by protein kinase C". Molecular and Cellular Endocrinology. 175 (1–2): 185–91. doi:10.1016/S0303-7207(01)00387-2. PMID 11325528.
  10. ^ Yoo JY, Wang XW, Rishi AK, Lessor T, Xia XM, Gustafson TA, Hamburger AW (February 2000). "Interaction of the PA2G4 (EBP1) protein with ErbB-3 and regulation of this binding by heregulin". British Journal of Cancer. 82 (3): 683–90. doi:10.1054/bjoc.1999.0981. PMC 2363329. PMID 10682683.
  11. ^ Xia X, Cheng A, Lessor T, Zhang Y, Hamburger AW (May 2001). "Ebp1, an ErbB-3 binding protein, interacts with Rb and affects Rb transcriptional regulation". Journal of Cellular Physiology. 187 (2): 209–17. doi:10.1002/jcp.1075. PMID 11268000.
  12. ^ Zhang Y, Fondell JD, Wang Q, Xia X, Cheng A, Lu ML, Hamburger AW (August 2002). "Repression of androgen receptor mediated transcription by the ErbB-3 binding protein, Ebp1". Oncogene. 21 (36): 5609–18. doi:10.1038/sj.onc.1205638. PMID 12165860.

Further reading[edit]