PADI2

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PADI2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPADI2, PAD-H19, PAD2, PDI2, peptidyl arginine deiminase 2
External IDsOMIM: 607935 MGI: 1338892 HomoloGene: 7214 GeneCards: PADI2
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for PADI2
Genomic location for PADI2
Band1p36.13Start17,066,761 bp[1]
End17,119,451 bp[1]
RNA expression pattern
PBB GE PADI2 209791 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007365

NM_008812

RefSeq (protein)

NP_031391

NP_032838

Location (UCSC)Chr 1: 17.07 – 17.12 MbChr 4: 140.91 – 140.95 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein-arginine deiminase type-2 is an enzyme that in humans is encoded by the PADI2 gene.[5][6]

This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages.

This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000117115 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028927 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Watanabe K, Senshu T (Oct 1989). "Isolation and characterization of cDNA clones encoding rat skeletal muscle peptidylarginine deiminase". J Biol Chem. 264 (26): 15255–60. PMID 2768262.
  6. ^ a b "Entrez Gene: PADI2 peptidyl arginine deiminase, type II".

Further reading[edit]