PAK3

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PAK3
Protein PAK3 PDB 1e0a.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PAK3, CDKN1A, MRX30, MRX47, OPHN3, PAK3beta, bPAK, hPAK-3, beta-PAK, ARA, p21 (RAC1) activated kinase 3
External IDs MGI: 1339656 HomoloGene: 55664 GeneCards: 5063
RNA expression pattern
PBB GE PAK3 214607 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001195046
NM_001195047
NM_001195048
NM_001195049
NM_008778

RefSeq (protein)

NP_001181977.1
NP_001181978.1
NP_032804.2

Location (UCSC) Chr X: 110.94 – 111.23 Mb Chr X: 143.52 – 143.8 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Serine/threonine-protein kinase PAK 3 is an enzyme that in humans is encoded by the PAK3 gene.[1][2][3]

Function[edit]

PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities. The protein encoded by this gene forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1 proteins which then catalyzes a variety of targets. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity.[3]

Clinical significance[edit]

A point mutation in this gene has been linked to nonsyndromic X-linked mental retardation.[3]

Interactions[edit]

PAK3 has been shown to interact with RAC1.[4]

References[edit]

  1. ^ Donnelly AJ, Partington MW, Ryan AK, Mulley JC (Nov 1996). "Regional localisation of two non-specific X-linked mental retardation genes (MRX30 and MRX31)". Am J Med Genet 64 (1): 113–20. doi:10.1002/(SICI)1096-8628(19960712)64:1<113::AID-AJMG19>3.0.CO;2-Q. PMID 8826460. 
  2. ^ Allen KM, Gleeson JG, Bagrodia S, Partington MW, MacMillan JC, Cerione RA, Mulley JC, Walsh CA (Oct 1998). "PAK3 mutation in nonsyndromic X-linked mental retardation". Nat Genet 20 (1): 25–30. doi:10.1038/1675. PMID 9731525. 
  3. ^ a b c "Entrez Gene: PAK3 p21 (CDKN1A)-activated kinase 3". 
  4. ^ Shin OH, Exton JH (Aug 2001). "Differential binding of arfaptin 2/POR1 to ADP-ribosylation factors and Rac1". Biochem. Biophys. Res. Commun. 285 (5): 1267–73. doi:10.1006/bbrc.2001.5330. PMID 11478794. 

Further reading[edit]

External links[edit]