PANX1

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PANX1
Identifiers
Aliases PANX1, MRS1, PX1, UNQ2529, pannexin 1
External IDs MGI: 1860055 HomoloGene: 49416 GeneCards: PANX1
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_015368

NM_019482

RefSeq (protein)

NP_056183

NP_062355.2
NP_062355

Location (UCSC) Chr 11: 94.13 – 94.18 Mb Chr 9: 15 – 15.05 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Pannexin 1 is a protein in humans that is encoded by the PANX1 gene.[3]

The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties.[3]

Clinical relevance[edit]

Truncating mutations in this gene have been shown to promote breast cancer metastasis to the lungs by allowing cancer cells to survive mechanical stretch in the microcirculation. [4]

Disruptions of this gene have been associated to melanoma tumor progression.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b "Entrez Gene: Pannexin 1". Retrieved 2012-04-11. 
  4. ^ Furlow PW, Zhang S, Soong TD, Halberg N, Goodarzi H, Mangrum C, Wu YG, Elemento O, Tavazoie SF (July 2015). "Mechanosensitive pannexin-1 channels mediate microvascular metastatic cell survival.". Nature Cell Biology (17): 943–952. doi:10.1038/ncb3194. PMID 26098574. 
  5. ^ Penuela S, Gyenis L, Ablack A, Churko JM, Berger AC, Litchfield DW, Lewis JD, Laird DW (Aug 2012). "Loss of pannexin 1 attenuates melanoma progression by reversion to a melanocytic phenotype". The Journal of Biological Chemistry. 287 (34): 29184–93. doi:10.1074/jbc.M112.377176. PMID 22753409. 

Further reading[edit]