PAPOLG

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PAPOLG
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPAPOLG, poly(A) polymerase gamma
External IDsOMIM: 616865 MGI: 2442119 HomoloGene: 56959 GeneCards: PAPOLG
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for PAPOLG
Genomic location for PAPOLG
Band2p16.1Start60,756,253 bp[1]
End60,802,086 bp[1]
RNA expression pattern
PBB GE PAPOLG 219160 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_022894

NM_172555

RefSeq (protein)

NP_075045

NP_766143

Location (UCSC)Chr 2: 60.76 – 60.8 MbChr 11: 23.86 – 23.9 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Poly(A) polymerase gamma is an enzyme that in humans is encoded by the PAPOLG gene.[5]

This gene encodes a member of the poly(A) polymerase family which catalyzes template-independent extension of the 3' end of a DNA/RNA strand. This enzyme shares 60% identity to the well characterized poly(A) polymerase II (PAPII) at the amino acid level. These two enzymes have similar organization of structural and functional domains. This enzyme is exclusively localized in the nucleus and exhibits both nonspecific and CPSF (cleavage and polyadenylation specificity factor)/AAUAAA-dependent polyadenylation activity. This gene is located on chromosome 2 in contrast to the PAPII gene, which is located on chromosome 14.[5]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000115421 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020273 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: PAPOLG poly(A) polymerase gamma".

Further reading[edit]