PAPSS2

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PAPSS2
Protein PAPSS2 PDB 2ax4.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PAPSS2, ATPSK2, BCYM4, SK2, 3'-phosphoadenosine 5'-phosphosulfate synthase 2
External IDs MGI: 1330223 HomoloGene: 55840 GeneCards: 9060
RNA expression pattern
PBB GE PAPSS2 203058 s at tn.png

PBB GE PAPSS2 203059 s at tn.png

PBB GE PAPSS2 203060 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004670
NM_001015880

NM_001201470
NM_011864

RefSeq (protein)

NP_001015880.1
NP_004661.2
NP_004661.2

NP_035994.2

Location (UCSC) Chr 10: 87.66 – 87.75 Mb Chr 19: 32.62 – 32.67 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 2 is an enzyme that in humans is encoded by the PAPSS2 gene.[1][2]

Sulfation is a common modification of endogenous (lipids, proteins, and carbohydrates) and exogenous (xenobiotics and drugs) compounds. In mammals, the sulfate source is 3'-phosphoadenosine 5'-phosphosulfate (PAPS), created from ATP and inorganic sulfate. Two different tissue isoforms encoded by different genes synthesize PAPS. This gene encodes one of the two PAPS synthetases. Defects in this gene cause the Pakistani type of spondyloepimetaphyseal dysplasia. Two alternatively spliced transcript variants that encode different isoforms have been described for this gene.[2]

References[edit]

  1. ^ ul Haque MF, King LM, Krakow D, Cantor RM, Rusiniak ME, Swank RT, Superti-Furga A, Haque S, Abbas H, Ahmad W, Ahmad M, Cohn DH (Oct 1998). "Mutations in orthologous genes in human spondyloepimetaphyseal dysplasia and the brachymorphic mouse". Nat Genet 20 (2): 157–62. doi:10.1038/2458. PMID 9771708. 
  2. ^ a b "Entrez Gene: PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2". 

Further reading[edit]