PAR1 (gene)

PWAR1
Identifiers
Aliases	PWAR1, D15S227E, PAR-1, PAR1, Prader Willi/Angelman region RNA 1
External IDs	OMIM: 600161 GeneCards: PWAR1
Gene location (Human) Chr. Chromosome 15 (human) Band 15q11.2 Start 25,135,642 bp End 25,138,055 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle skeletal muscle tissue muscle of leg ganglionic eminence right lobe of thyroid gland prefrontal cortex superior frontal gyrus left lobe of thyroid gland corpus callosum kidney n/a More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 145624 n/a Ensembl ENSG00000279050 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 15: 25.14 – 25.14 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

Prader-Willi/Angelman region-1, also known as PWAR1, is an exon of the lncRNA Small nucleolar RNA host gene 14 (SNHG14).

Further reading

• Sutcliffe JS, Nakao M, Christian S, et al. (1995). "Deletions of a differentially methylated CpG island at the SNRPN gene define a putative imprinting control region". Nat. Genet. 8 (1): 52–8. doi:10.1038/ng0994-52. PMID 7987392. S2CID 31504627.
• Schulze A, Hansen C, Skakkebaek NE, et al. (1996). "Exclusion of SNRPN as a major determinant of Prader-Willi syndrome by a translocation breakpoint". Nat. Genet. 12 (4): 452–4. doi:10.1038/ng0496-452. PMID 8630505. S2CID 22259236.
• Christian SL, Bhatt NK, Martin SA, et al. (1998). "Integrated YAC contig map of the Prader-Willi/Angelman region on chromosome 15q11-q13 with average STS spacing of 35 kb". Genome Res. 8 (2): 146–57. doi:10.1101/gr.8.2.146. PMC 310691. PMID 9477342.
• Wirth J, Back E, Hüttenhofer A, et al. (2001). "A translocation breakpoint cluster disrupts the newly defined 3' end of the SNURF-SNRPN transcription unit on chromosome 15". Hum. Mol. Genet. 10 (3): 201–10. doi:10.1093/hmg/10.3.201. PMID 11159938.
• Dorsam RT, Tuluc M, Kunapuli SP (2005). "Role of protease-activated and ADP receptor subtypes in thrombin generation on human platelets". J. Thromb. Haemost. 2 (5): 804–12. doi:10.1111/j.1538-7836.2004.00692.x. PMID 15099288. S2CID 20124469.
• Nakayama T, Hirano K, Hirano M, et al. (2004). "Inactivation of protease-activated receptor-1 by proteolytic removal of the ligand region in vascular endothelial cells". Biochem. Pharmacol. 68 (1): 23–32. doi:10.1016/j.bcp.2004.03.005. PMID 15183114.
• Shi X, Gangadharan B, Brass LF, et al. (2005). "Protease-activated receptors (PAR1 and PAR2) contribute to tumor cell motility and metastasis". Mol. Cancer Res. 2 (7): 395–402. doi:10.1158/1541-7786.395.2.7. PMID 15280447. S2CID 31329993.
• Heider I, Schulze B, Oswald E, et al. (2005). "PAR1-type thrombin receptor stimulates migration and matrix adhesion of human colon carcinoma cells by a PKCepsilon-dependent mechanism". Oncol. Res. 14 (10): 475–82. doi:10.3727/0965040042380496. PMID 15559761.
• Tantivejkul K, Loberg RD, Mawocha SC, et al. (2005). "PAR1-mediated NFkappaB activation promotes survival of prostate cancer cells through a Bcl-xL-dependent mechanism" (PDF). J. Cell. Biochem. 96 (3): 641–52. doi:10.1002/jcb.20533. hdl:2027.42/48764. PMID 16052512. S2CID 34707839.