PARD3

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PARD3
Protein PARD3 PDB 2KOM.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PARD3, ASIP, Baz, PAR3, PAR3alpha, PARD-3, PARD3A, PPP1R118, SE2-5L16, SE2-5LT1, SE2-5T2, par-3 family cell polarity regulator
External IDs MGI: 2135608 HomoloGene: 10489 GeneCards: PARD3
Genetically Related Diseases
lymphoblastic leukemia[1]
RNA expression pattern
PBB GE PARD3 210094 s at fs.png

PBB GE PARD3 221526 x at fs.png

PBB GE PARD3 221280 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC) Chr 10: 34.11 – 34.82 Mb Chr 8: 127.06 – 127.61 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Partitioning defective 3 homolog is a protein that in humans is encoded by the PARD3 gene.[4][5]

Function[edit]

PARD proteins, which were first identified in C. elegans, are essential for asymmetric cell division and polarized growth, whereas CDC42 (MIM 116952) mediates the establishment of cell polarity. The CDC42 GTPase, which is controlled by nucleotide exchange factors (GEFs; see MIM 606057) and GTPase-activating proteins (GAPs; see MIM 604980), interacts with a large set of effector proteins that typically contain a CDC42/RAC (MIM 602048)-interactive binding (CRIB) domain.[supplied by OMIM][5]

Interactions[edit]

PARD3 has been shown to interact with:

References[edit]

  1. ^ "Diseases that are genetically associated with PARD3 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Joberty G, Petersen C, Gao L, Macara IG (Oct 2000). "The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42". Nat Cell Biol. 2 (8): 531–9. doi:10.1038/35019573. PMID 10934474. 
  5. ^ a b "Entrez Gene: PARD3 par-3 partitioning defective 3 homolog (C. elegans)". 
  6. ^ a b Ebnet K, Aurrand-Lions M, Kuhn A, Kiefer F, Butz S, Zander K, Meyer zu Brickwedde MK, Suzuki A, Imhof BA, Vestweber D (Oct 2003). "The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity". J. Cell. Sci. 116 (Pt 19): 3879–91. doi:10.1242/jcs.00704. PMID 12953056. 
  7. ^ Kohjima M, Noda Y, Takeya R, Saito N, Takeuchi K, Sumimoto H (Dec 2002). "PAR3beta, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions". Biochem. Biophys. Res. Commun. 299 (4): 641–6. doi:10.1016/s0006-291x(02)02698-0. PMID 12459187. 
  8. ^ Takekuni K, Ikeda W, Fujito T, Morimoto K, Takeuchi M, Monden M, Takai Y (Feb 2003). "Direct binding of cell polarity protein PAR-3 to cell-cell adhesion molecule nectin at neuroepithelial cells of developing mouse". J. Biol. Chem. 278 (8): 5497–500. doi:10.1074/jbc.C200707200. PMID 12515806. 

Further reading[edit]