PARD6B

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PARD6B
Protein PARD6B PDB 1nf3.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PARD6B, PAR6B, par-6 family cell polarity regulator beta
External IDs MGI: 2135605 HomoloGene: 23302 GeneCards: PARD6B
Gene location (Human)
Chromosome 20 (human)
Chr. Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for PARD6B
Genomic location for PARD6B
Band 20q13.13 Start 50,731,544 bp[1]
End 50,756,795 bp[1]
RNA expression pattern
PBB GE PARD6B 214827 at fs.png

PBB GE PARD6B 211907 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_032521

NM_021409

RefSeq (protein)

NP_115910

NP_067384

Location (UCSC) Chr 20: 50.73 – 50.76 Mb Chr 20: 168.08 – 168.1 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Partitioning defective 6 homolog beta is a protein that in humans is encoded by the PARD6B gene.[5][6]

Function[edit]

This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain, an OPR domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cytoplasmic protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex.[6]

Interactions[edit]

PARD6B has been shown to interact with:

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000124171 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000044641 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ a b c d Noda Y, Takeya R, Ohno S, Naito S, Ito T, Sumimoto H (March 2001). "Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C". Genes Cells. 6 (2): 107–19. doi:10.1046/j.1365-2443.2001.00404.x. PMID 11260256. 
  6. ^ a b "Entrez Gene: PARD6B par-6 partitioning defective 6 homolog beta (C. elegans)". 
  7. ^ a b Neudauer CL, Joberty G, Macara IG (January 2001). "PIST: a novel PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10". Biochem. Biophys. Res. Commun. 280 (2): 541–7. doi:10.1006/bbrc.2000.4160. PMID 11162552. 
  8. ^ a b Joberty G, Petersen C, Gao L, Macara IG (August 2000). "The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42". Nat. Cell Biol. 2 (8): 531–9. doi:10.1038/35019573. PMID 10934474. 

Further reading[edit]