PARK7

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Parkinson protein 7
Protein PARK7 PDB 1j42.png
PDB rendering based on 1j42 [1].
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PARK7 ; DJ-1; DJ1; HEL-S-67p
External IDs OMIM602533 MGI2135637 HomoloGene38295 GeneCards: PARK7 Gene
RNA expression pattern
PBB GE PARK7 200007 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 11315 57320
Ensembl ENSG00000116288 ENSMUSG00000028964
UniProt Q99497 Q99LX0
RefSeq (mRNA) NM_001123377 NM_020569
RefSeq (protein) NP_001116849 NP_065594
Location (UCSC) Chr 1:
7.95 – 7.99 Mb
Chr 4:
150.9 – 150.91 Mb
PubMed search [1] [2]

Protein deglycase DJ-1, also known as Parkinson disease protein 7, is a protein which in humans is encoded by the PARK7 gene.[2]

Gene[edit]

The gene PARK7, also known as DJ-1, encodes a protein of the peptidase C56 family. The human gene PARK7 has 8 Exons and locates at chromosome band 1p36.23.[2]

Protein[edit]

The human protein deglycase DJ-1 is 20 kDa in size and composed of 189 amino acids with seven β-strands and nine α-helices in total and is present as a dimer.[3][4][5]

Function[edit]

PARK7 belongs to the peptidase C56 family of proteins. The protein structures of human protein DJ-1, Escherichia coli chaperone Hsp31 and an Archaea protease are evolutionarily conserved.[6] Under an oxidative condition, protein deglycase DJ-1 inhibits the aggregation of α-synuclein via its chaperone activity,[7][8] thus functions as a redox-sensitive chaperone and as a sensor for oxidative stress. Accordingly, DJ-1 apparently protects neurons against oxidative stress and cell death.[2] In parallel, Protein DJ-1 acts as a positive regulator of androgen receptor-dependent transcription.

Clinical significance[edit]

Defects in this gene are the cause of autosomal recessive early-onset Parkinson's disease 7.[2][9]

Interactions[edit]

PARK7 has been shown to interact with:

See also[edit]

References[edit]

  1. ^ Lee, S. J.; Kim, S. J.; Kim, I. K.; Ko, J.; Jeong, C. S.; Kim, G. H.; Park, C.; Kang, S. O.; Suh, P. G. (2003). "Crystal Structures of Human DJ-1 and Escherichia coli Hsp31, Which Share an Evolutionarily Conserved Domain". Journal of Biological Chemistry 278 (45): 44552–44559. doi:10.1074/jbc.M304517200. PMID 12939276.  edit
  2. ^ a b c d "Entrez Gene: PARK7". 
  3. ^ "Uniprot: Q99497 - PARK7_HUMAN". 
  4. ^ Honbou K, Suzuki NN, Horiuchi M, Niki T, Taira T, Ariga H et al. (Aug 2003). "The crystal structure of DJ-1, a protein related to male fertility and Parkinson's disease". The Journal of Biological Chemistry 278 (33): 31380–4. doi:10.1074/jbc.M305878200. PMID 12796482. 
  5. ^ Tao X, Tong L (Aug 2003). "Crystal structure of human DJ-1, a protein associated with early onset Parkinson's disease". The Journal of Biological Chemistry 278 (33): 31372–9. doi:10.1074/jbc.M304221200. PMID 12761214. 
  6. ^ Lee SJ, Kim SJ, Kim IK, Ko J, Jeong CS, Kim GH et al. (Nov 2003). "Crystal structures of human DJ-1 and Escherichia coli Hsp31, which share an evolutionarily conserved domain". The Journal of Biological Chemistry 278 (45): 44552–9. doi:10.1074/jbc.M304517200. PMID 12939276. 
  7. ^ Shendelman S, Jonason A, Martinat C, Leete T, Abeliovich A (Nov 2004). "DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation". PLoS Biology 2 (11): e362. doi:10.1371/journal.pbio.0020362. PMID 15502874. 
  8. ^ Zhou W, Zhu M, Wilson MA, Petsko GA, Fink AL (Mar 2006). "The oxidation state of DJ-1 regulates its chaperone activity toward alpha-synuclein". Journal of Molecular Biology 356 (4): 1036–48. doi:10.1016/j.jmb.2005.12.030. PMID 16403519. 
  9. ^ Bonifati V, Rizzu P, van Baren MJ, Schaap O, Breedveld GJ, Krieger E et al. (Jan 2003). "Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism". Science 299 (5604): 256–9. doi:10.1126/science.1077209. PMID 12446870. 
  10. ^ Mukherjee K, Slawson JB, Christmann BL, Griffith LC (2014). "Neuron-specific protein interactions of Drosophila CASK-β are revealed by mass spectrometry". Frontiers in Molecular Neuroscience 7: 58. doi:10.3389/fnmol.2014.00058. PMC 4075472. PMID 25071438. 
  11. ^ Niki T, Takahashi-Niki K, Taira T, Iguchi-Ariga SM, Ariga H (Feb 2003). "DJBP: a novel DJ-1-binding protein, negatively regulates the androgen receptor by recruiting histone deacetylase complex, and DJ-1 antagonizes this inhibition by abrogation of this complex". Molecular Cancer Research 1 (4): 247–61. PMID 12612053. 
  12. ^ Takahashi K, Taira T, Niki T, Seino C, Iguchi-Ariga SM, Ariga H (Oct 2001). "DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor". The Journal of Biological Chemistry 276 (40): 37556–63. doi:10.1074/jbc.M101730200. PMID 11477070. 

Further reading[edit]

  • Cookson MR (Jan 2003). "Pathways to Parkinsonism". Neuron 37 (1): 7–10. doi:10.1016/S0896-6273(02)01166-2. PMID 12526767. 
  • Bonifati V, Oostra BA, Heutink P (Mar 2004). "Linking DJ-1 to neurodegeneration offers novel insights for understanding the pathogenesis of Parkinson's disease". Journal of Molecular Medicine 82 (3): 163–74. doi:10.1007/s00109-003-0512-1. PMID 14712351. 
  • Le W, Appel SH (Feb 2004). "Mutant genes responsible for Parkinson's disease". Current Opinion in Pharmacology 4 (1): 79–84. doi:10.1016/j.coph.2003.09.005. PMID 15018843. 
  • Abou-Sleiman PM, Healy DG, Wood NW (Oct 2004). "Causes of Parkinson's disease: genetics of DJ-1". Cell and Tissue Research 318 (1): 185–8. doi:10.1007/s00441-004-0922-6. PMID 15503154. 
  • Pankratz N, Foroud T (Apr 2004). "Genetics of Parkinson disease". NeuroRx 1 (2): 235–42. doi:10.1602/neurorx.1.2.235. PMC 534935. PMID 15717024. 
  • Heutink P (2006). "PINK-1 and DJ-1--new genes for autosomal recessive Parkinson's disease". Journal of Neural Transmission. Supplementum. Journal of Neural Transmission. Supplementa 70 (70): 215–9. doi:10.1007/978-3-211-45295-0_33. ISBN 978-3-211-28927-3. PMID 17017532. 
  • Lev N, Roncevic D, Roncevich D, Ickowicz D, Melamed E, Offen D (2007). "Role of DJ-1 in Parkinson's disease". Journal of Molecular Neuroscience 29 (3): 215–25. doi:10.1385/JMN:29:3:215. PMID 17085780. 
  • Nagakubo D, Taira T, Kitaura H, Ikeda M, Tamai K, Iguchi-Ariga SM et al. (Feb 1997). "DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras". Biochemical and Biophysical Research Communications 231 (2): 509–13. doi:10.1006/bbrc.1997.6132. PMID 9070310. 
  • Taira T, Takahashi K, Kitagawa R, Iguchi-Ariga SM, Ariga H (Jan 2001). "Molecular cloning of human and mouse DJ-1 genes and identification of Sp1-dependent activation of the human DJ-1 promoter". Gene 263 (1-2): 285–92. doi:10.1016/S0378-1119(00)00590-4. PMID 11223268. 
  • van Duijn CM, Dekker MC, Bonifati V, Galjaard RJ, Houwing-Duistermaat JJ, Snijders PJ et al. (Sep 2001). "Park7, a novel locus for autosomal recessive early-onset parkinsonism, on chromosome 1p36". American Journal of Human Genetics 69 (3): 629–34. doi:10.1086/322996. PMC 1235491. PMID 11462174. 
  • Takahashi K, Taira T, Niki T, Seino C, Iguchi-Ariga SM, Ariga H (Oct 2001). "DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor". The Journal of Biological Chemistry 276 (40): 37556–63. doi:10.1074/jbc.M101730200. PMID 11477070. 
  • Bonifati V, Rizzu P, van Baren MJ, Schaap O, Breedveld GJ, Krieger E et al. (Jan 2003). "Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism". Science 299 (5604): 256–9. doi:10.1126/science.1077209. PMID 12446870. 
  • Bonifati V, Dekker MC, Vanacore N, Fabbrini G, Squitieri F, Marconi R et al. (Sep 2002). "Autosomal recessive early onset parkinsonism is linked to three loci: PARK2, PARK6, and PARK7". Neurological Sciences. 23 Suppl 2: S59–60. doi:10.1007/s100720200069. PMID 12548343. 
  • Niki T, Takahashi-Niki K, Taira T, Iguchi-Ariga SM, Ariga H (Feb 2003). "DJBP: a novel DJ-1-binding protein, negatively regulates the androgen receptor by recruiting histone deacetylase complex, and DJ-1 antagonizes this inhibition by abrogation of this complex". Molecular Cancer Research 1 (4): 247–61. PMID 12612053. 
  • Tao X, Tong L (Aug 2003). "Crystal structure of human DJ-1, a protein associated with early onset Parkinson's disease". The Journal of Biological Chemistry 278 (33): 31372–9. doi:10.1074/jbc.M304221200. PMID 12761214. 
  • Honbou K, Suzuki NN, Horiuchi M, Niki T, Taira T, Ariga H et al. (Aug 2003). "The crystal structure of DJ-1, a protein related to male fertility and Parkinson's disease". The Journal of Biological Chemistry 278 (33): 31380–4. doi:10.1074/jbc.M305878200. PMID 12796482. 
  • Dekker M, Bonifati V, van Swieten J, Leenders N, Galjaard RJ, Snijders P et al. (Jul 2003). "Clinical features and neuroimaging of PARK7-linked parkinsonism". Movement Disorders 18 (7): 751–7. doi:10.1002/mds.10422. PMID 12815653. 
  • Miller DW, Ahmad R, Hague S, Baptista MJ, Canet-Aviles R, McLendon C et al. (Sep 2003). "L166P mutant DJ-1, causative for recessive Parkinson's disease, is degraded through the ubiquitin-proteasome system". The Journal of Biological Chemistry 278 (38): 36588–95. doi:10.1074/jbc.M304272200. PMID 12851414. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.