Poly(A)-specific ribonuclease

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Poly(A)-specific ribonuclease
Protein PARN PDB 1whv.png
PDB rendering based on 1whv.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM604212 MGI1921358 HomoloGene31098 GeneCards: PARN Gene
EC number
RNA expression pattern
PBB GE PARN 203905 at tn.png
More reference expression data
Species Human Mouse
Entrez 5073 74108
Ensembl ENSG00000140694 ENSMUSG00000022685
UniProt O95453 Q8VDG3
RefSeq (mRNA) NM_001134477 NM_028761
RefSeq (protein) NP_001127949 NP_083037
Location (UCSC) Chr 16:
14.44 – 14.63 Mb
Chr 16:
13.54 – 13.67 Mb
PubMed search [1] [2]

Poly(A)-specific ribonuclease (PARN), also known as polyadenylate-specific ribonuclease or deadenylating nuclease (DAN), is an enzyme that in humans is encoded by the PARN gene.[1][2]


Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. The amino acid sequence of poly(A)-specific ribonuclease shows homology to the RNase D family of 3'-exonucleases. The protein appears to be localized in both the nucleus and the cytoplasm. It is not stably associated with polysomes or ribosomal subunits.[2]


  1. ^ Buiting K, Korner C, Ulrich B, Wahle E, Horsthemke B (May 2000). "The human gene for the poly(A)-specific ribonuclease (PARN) maps to 16p13 and has a truncated copy in the Prader-Willi/Angelman syndrome region on 15q11→q13". Cytogenet Cell Genet 87 (1–2): 125–31. doi:10.1159/000015378. PMID 10640832. 
  2. ^ a b "Entrez Gene: PARN poly(A)-specific ribonuclease (deadenylation nuclease)". 

Further reading[edit]