PARP2

From Wikipedia, the free encyclopedia
Jump to: navigation, search
PARP2
Protein PARP2 PDB 1gs0.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PARP2, ADPRT2, ADPRTL2, ADPRTL3, ARTD2, PARP-2, pADPRT-2, poly(ADP-ribose) polymerase 2
External IDs MGI: 1341112 HomoloGene: 4004 GeneCards: PARP2
Gene location (Human)
Chromosome 14 (human)
Chr. Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for PARP2
Genomic location for PARP2
Band 14q11.2 Start 20,343,582 bp[1]
End 20,357,905 bp[1]
RNA expression pattern
PBB GE PARP2 204752 x at fs.png

PBB GE PARP2 215773 x at fs.png

PBB GE PARP2 214086 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001042618
NM_005484

NM_009632

RefSeq (protein)

NP_001036083
NP_005475

NP_033762

Location (UCSC) Chr 14: 20.34 – 20.36 Mb Chr 14: 50.81 – 50.82 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Poly [ADP-ribose] polymerase 2 is an enzyme that in humans is encoded by the PARP2 gene.[5][6][7] It is one of the PARP family of enzymes.

Function[edit]

This gene encodes poly(ADP-ribosyl)transferase-like 2 protein, which contains a catalytic domain and is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. The basic residues within the N-terminal region of this protein may bear potential DNA-binding properties, and may be involved in the nuclear and/or nucleolar targeting of the protein. Two alternatively spliced transcript variants encoding distinct isoforms have been found.[7]

PARP inhibitor drugs[edit]

Some PARP inhibitor anti-cancer drugs (primarily aimed at PARP1) also inhibit PARP2, e.g. niraparib.

Interactions[edit]

PARP2 has been shown to interact with XRCC1.[8]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000129484 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036023 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Johansson M (Aug 1999). "A human poly(ADP-ribose) polymerase gene family (ADPRTL): cDNA cloning of two novel poly(ADP-ribose) polymerase homologues". Genomics. 57 (3): 442–5. doi:10.1006/geno.1999.5799. PMID 10329013. 
  6. ^ Yélamos J, Schreiber V, Dantzer F (Apr 2008). "Toward specific functions of poly(ADP-ribose) polymerase-2". Trends Mol Med. 14 (4): 169–78. doi:10.1016/j.molmed.2008.02.003. PMID 18353725. 
  7. ^ a b "Entrez Gene: PARP2 poly (ADP-ribose) polymerase family, member 2". 
  8. ^ Schreiber V, Amé JC, Dollé P, Schultz I, Rinaldi B, Fraulob V, Ménissier-de Murcia J, de Murcia G (Jun 2002). "Poly(ADP-ribose) polymerase-2 (PARP-2) is required for efficient base excision DNA repair in association with PARP-1 and XRCC1". J. Biol. Chem. United States. 277 (25): 23028–36. doi:10.1074/jbc.M202390200. ISSN 0021-9258. PMID 11948190. 

Further reading[edit]

External links[edit]