PARP3

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PARP3
Protein PARP3 PDB 2pa9.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPARP3, ADPRT3, ADPRTL2, ADPRTL3, ARTD3, IRT1, PADPRT-3, poly(ADP-ribose) polymerase family member 3
External IDsMGI: 1891258 HomoloGene: 4005 GeneCards: PARP3
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for PARP3
Genomic location for PARP3
Band3p21.2Start51,942,345 bp[1]
End51,948,867 bp[1]
RNA expression pattern
PBB GE PARP3 209940 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001003931
NM_001003935
NM_005485
NM_001370239
NM_001370240

NM_145619
NM_001311150

RefSeq (protein)

NP_001003931
NP_005476
NP_001357168
NP_001357169

NP_001298079
NP_663594

Location (UCSC)Chr 3: 51.94 – 51.95 MbChr 9: 106.47 – 106.48 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Poly [ADP-ribose] polymerase 3 is an enzyme that in humans is encoded by the PARP3 gene.[5][6]

The protein encoded by this gene belongs to the PARP family. These enzymes modify nuclear proteins by poly-ADP-ribosylation, which is required for DNA repair, regulation of apoptosis, and maintenance of genomic stability. This gene encodes the poly(ADP-ribosyl)transferase 3, which is preferentially localized to the daughter centriole throughout the cell cycle. Alternatively spliced transcript variants encoding different isoforms have been identified.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000041880 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023249 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Johansson M (Aug 1999). "A human poly(ADP-ribose) polymerase gene family (ADPRTL): cDNA cloning of two novel poly(ADP-ribose) polymerase homologues". Genomics. 57 (3): 442–5. doi:10.1006/geno.1999.5799. PMID 10329013.
  6. ^ a b "Entrez Gene: PARP3 poly (ADP-ribose) polymerase family, member 3".

Further reading[edit]

External links[edit]