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Pre-B-cell leukemia homeobox 1
HoxB1-Pbx1 heterodimer binding DNA 1b72.png
Cartoon diagram of a HOXB1–PBX1 heterodimer (violet) binding a DNA fragment (blue). Rendering based on PDB 1b72.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PBX1 ; DKFZp686B09108; MGC126627
External IDs OMIM176310 MGI97495 HomoloGene20574 ChEMBL: 4587 GeneCards: PBX1 Gene
RNA expression pattern
PBB GE PBX1 205253 at tn.png
More reference expression data
Species Human Mouse
Entrez 5087 18514
Ensembl ENSG00000185630 ENSMUSG00000052534
UniProt P40424 P41778
RefSeq (mRNA) NM_001204961 NM_001291508
RefSeq (protein) NP_001191890 NP_001278437
Location (UCSC) Chr 1:
164.56 – 164.9 Mb
Chr 1:
168.12 – 168.43 Mb
PubMed search [1] [2]

Pre-B-cell leukemia transcription factor 1 is a protein that in humans is encoded by the PBX1 gene.[1]


PBX1 has been shown to interact with HOXB1,[2][3] MEIS1, [4] [5] [6] Prep1,[7] and HOXB7.[8]


  1. ^ "Entrez Gene: PBX1 Pre-B-cell leukemia homeobox 1". 
  2. ^ Berthelsen, J; Zappavigna V; Ferretti E; Mavilio F; Blasi F (Mar 1998). "The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity". EMBO J. (ENGLAND) 17 (5): 1434–45. doi:10.1093/emboj/17.5.1434. ISSN 0261-4189. PMC 1170491. PMID 9482740. 
  3. ^ Piper, D E; Batchelor A H; Chang C P; Cleary M L; Wolberger C (Feb 1999). "Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation". Cell (UNITED STATES) 96 (4): 587–97. doi:10.1016/S0092-8674(00)80662-5. ISSN 0092-8674. PMID 10052460. 
  4. ^ Shen, W F; Rozenfeld S; Kwong A; Köm ves L G; Lawrence H J; Largman C (Apr 1999). "HOXA9 Forms Triple Complexes with PBX2 and MEIS1 in Myeloid Cells". Mol. Cell. Biol. (UNITED STATES) 19 (4): 3051–61. ISSN 0270-7306. PMC 84099. PMID 10082572. 
  5. ^ Shanmugam, K; Green N C; Rambaldi I; Saragovi H U; Featherstone M S (Nov 1999). "PBX and MEIS as Non-DNA-Binding Partners in Trimeric Complexes with HOX Proteins". Mol. Cell. Biol. (UNITED STATES) 19 (11): 7577–88. ISSN 0270-7306. PMC 84774. PMID 10523646. 
  6. ^ Jacobs, Y; Schnabel C A; Cleary M L (Jul 1999). "Trimeric Association of Hox and TALE Homeodomain Proteins Mediates Hoxb2 Hindbrain Enhancer Activity". Mol. Cell. Biol. (UNITED STATES) 19 (7): 5134–42. ISSN 0270-7306. PMC 84356. PMID 10373562. 
  7. ^ Zubair, M; Ishihara S; Okumura K; Morohashi K-I (Jun 2006). "Two-step regulation of Ad4BP/SF-1 gene transcription during fetal adrenal development: initiation by a Hox-Pbx1-Prep1 complex and maintenance via autoregulation by Ad4BP/SF-1". Mol. Cell. Biol. 26 (11): 4111–21. doi:10.1128/MCB.00222-06. PMID 16705164. 
  8. ^ Chang, C P; Shen W F; Rozenfeld S; Lawrence H J; Largman C; Cleary M L (Mar 1995). "Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins". Genes Dev. (UNITED STATES) 9 (6): 663–74. doi:10.1101/gad.9.6.663. ISSN 0890-9369. PMID 7729685. 

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