PBX1

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PBX1
HoxB1-Pbx1 heterodimer binding DNA 1b72.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PBX1
External IDs MGI: 97495 HomoloGene: 20574 GeneCards: 5087
Genetically Related Diseases
Disease Name References
breast cancer
RNA expression pattern
PBB GE PBX1 205253 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001204961
NM_001204963
NM_002585

NM_001291508
NM_001291509
NM_008783
NM_183355

RefSeq (protein)

NP_001191892.1
NP_002576.1

NP_001278437.1
NP_032809.1
NP_899198.1

Location (UCSC) Chr 1: 164.56 – 164.9 Mb Chr 1: 168.12 – 168.43 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Pre-B-cell leukemia transcription factor 1 is a protein that in humans is encoded by the PBX1 gene.[4]

Interactions[edit]

PBX1 has been shown to interact with:

References[edit]

  1. ^ "chibi.ubc.ca/Gemma/phenotypes.html?phenotypeUrlId=DOID_1612&geneId=121752". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ "Entrez Gene: PBX1 Pre-B-cell leukemia homeobox 1". 
  5. ^ Berthelsen J, Zappavigna V, Ferretti E, Mavilio F, Blasi F (Mar 1998). "The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity". The EMBO Journal. 17 (5): 1434–45. doi:10.1093/emboj/17.5.1434. PMC 1170491free to read. PMID 9482740. 
  6. ^ Piper DE, Batchelor AH, Chang CP, Cleary ML, Wolberger C (Feb 1999). "Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation". Cell. 96 (4): 587–97. doi:10.1016/S0092-8674(00)80662-5. PMID 10052460. 
  7. ^ Chang CP, Shen WF, Rozenfeld S, Lawrence HJ, Largman C, Cleary ML (Mar 1995). "Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins". Genes & Development. 9 (6): 663–74. doi:10.1101/gad.9.6.663. PMID 7729685. 
  8. ^ Shen WF, Rozenfeld S, Kwong A, Köm ves LG, Lawrence HJ, Largman C (Apr 1999). "HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells". Molecular and Cellular Biology. 19 (4): 3051–61. PMC 84099free to read. PMID 10082572. 
  9. ^ Shanmugam K, Green NC, Rambaldi I, Saragovi HU, Featherstone MS (Nov 1999). "PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins". Molecular and Cellular Biology. 19 (11): 7577–88. PMC 84774free to read. PMID 10523646. 
  10. ^ Jacobs Y, Schnabel CA, Cleary ML (Jul 1999). "Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity". Molecular and Cellular Biology. 19 (7): 5134–42. PMC 84356free to read. PMID 10373562. 
  11. ^ Zubair M, Ishihara S, Oka S, Okumura K, Morohashi K (Jun 2006). "Two-step regulation of Ad4BP/SF-1 gene transcription during fetal adrenal development: initiation by a Hox-Pbx1-Prep1 complex and maintenance via autoregulation by Ad4BP/SF-1". Molecular and Cellular Biology. 26 (11): 4111–21. doi:10.1128/MCB.00222-06. PMC 1489093free to read. PMID 16705164. 

Further reading[edit]

External links[edit]