PBX1

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PBX1
HoxB1-Pbx1 heterodimer binding DNA 1b72.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PBX1, PBX homeobox 1
External IDs MGI: 97495 HomoloGene: 20574 GeneCards: PBX1
RNA expression pattern
PBB GE PBX1 205253 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001204961
NM_001204963
NM_002585

NM_001291508
NM_001291509
NM_008783
NM_183355

RefSeq (protein)

NP_001191890
NP_001191892
NP_002576

Location (UCSC) Chr 1: 164.56 – 164.9 Mb Chr 1: 168.12 – 168.43 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Pre-B-cell leukemia transcription factor 1 is a protein that in humans is encoded by the PBX1 gene.[3]

Interactions[edit]

PBX1 has been shown to interact with:

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ "Entrez Gene: PBX1 Pre-B-cell leukemia homeobox 1". 
  4. ^ Berthelsen J, Zappavigna V, Ferretti E, Mavilio F, Blasi F (Mar 1998). "The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity". The EMBO Journal. 17 (5): 1434–45. doi:10.1093/emboj/17.5.1434. PMC 1170491Freely accessible. PMID 9482740. 
  5. ^ Piper DE, Batchelor AH, Chang CP, Cleary ML, Wolberger C (Feb 1999). "Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation". Cell. 96 (4): 587–97. doi:10.1016/S0092-8674(00)80662-5. PMID 10052460. 
  6. ^ Chang CP, Shen WF, Rozenfeld S, Lawrence HJ, Largman C, Cleary ML (Mar 1995). "Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins". Genes & Development. 9 (6): 663–74. doi:10.1101/gad.9.6.663. PMID 7729685. 
  7. ^ Shen WF, Rozenfeld S, Kwong A, Köm ves LG, Lawrence HJ, Largman C (Apr 1999). "HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells". Molecular and Cellular Biology. 19 (4): 3051–61. PMC 84099Freely accessible. PMID 10082572. 
  8. ^ Shanmugam K, Green NC, Rambaldi I, Saragovi HU, Featherstone MS (Nov 1999). "PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins". Molecular and Cellular Biology. 19 (11): 7577–88. PMC 84774Freely accessible. PMID 10523646. 
  9. ^ Jacobs Y, Schnabel CA, Cleary ML (Jul 1999). "Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity". Molecular and Cellular Biology. 19 (7): 5134–42. PMC 84356Freely accessible. PMID 10373562. 
  10. ^ Zubair M, Ishihara S, Oka S, Okumura K, Morohashi K (Jun 2006). "Two-step regulation of Ad4BP/SF-1 gene transcription during fetal adrenal development: initiation by a Hox-Pbx1-Prep1 complex and maintenance via autoregulation by Ad4BP/SF-1". Molecular and Cellular Biology. 26 (11): 4111–21. doi:10.1128/MCB.00222-06. PMC 1489093Freely accessible. PMID 16705164. 

Further reading[edit]

External links[edit]