PCBP1

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PCBP1
Protein PCBP1 PDB 1wvn.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPCBP1, HEL-S-85, HNRPE1, HNRPX, hnRNP-E1, hnRNP-X, poly(rC) binding protein 1
External IDsOMIM: 601209 MGI: 1345635 HomoloGene: 68506 GeneCards: PCBP1
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for PCBP1
Genomic location for PCBP1
Band2p13.3Start70,087,477 bp[1]
End70,089,203 bp[1]
RNA expression pattern
PBB GE PCBP1 208620 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006196

NM_011865

RefSeq (protein)

NP_006187

NP_035995

Location (UCSC)Chr 2: 70.09 – 70.09 MbChr 6: 86.52 – 86.53 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Poly(rC)-binding protein 1 is a protein that in humans is encoded by the PCBP1 gene.[5]

This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP2 and HNRPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure.

It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000169564 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000051695 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Tommerup N, Leffers H (May 1997). "Assignment of human KH-box-containing genes by in situ hybridization: HNRNPK maps to 9q21.32-q21.33, PCBP1 to 2p12-p13, and PCBP2 to 12q13.12-q13.13, distal to FRA12A". Genomics. 32 (2): 297–8. doi:10.1006/geno.1996.0121. PMID 8833161.
  6. ^ "Entrez Gene: PCBP1 poly(rC) binding protein 1".

Further reading[edit]