PCBP2

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PCBP2
Protein PCBP2 PDB 1ztg.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PCBP2, HNRNPE2, HNRPE2, hnRNP-E2, poly(rC) binding protein 2
External IDs MGI: 108202 HomoloGene: 74536 GeneCards: 5094
RNA expression pattern
PBB GE PCBP2 204031 s at tn.png

PBB GE PCBP2 213263 s at tn.png

PBB GE PCBP2 213264 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001103165
NM_001103166
NM_001174073
NM_011042

RefSeq (protein)

NP_001096635.1
NP_001096636.1
NP_035172.2

Location (UCSC) Chr 12: 53.45 – 53.48 Mb Chr 15: 102.47 – 102.5 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Poly(rC)-binding protein 2 is a protein that in humans is encoded by the PCBP2 gene.[1]

Function[edit]

The protein encoded by this gene appears to be multifunctional. It along with PCBP-1 and hnRNPK corresponds to the major cellular poly(rC)-binding proteins. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-1 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1 intronless gene which has similar functions. This gene and PCBP-1 has paralogues PCBP3 and PCBP4 which is thought to arose as a result of duplication events of entire genes. It also has two processed pseudogenes PCBP2P1 and PCBP2P2. There are presently two alternatively spliced transcript variants described for this gene.[2]

In humans, the PCBP2 gene overlaps with TUC338, a transcribed ultra-conserved element implicated in Hepatocellular carcinoma.[3]

Interactions[edit]

PCBP2 has been shown to interact with HNRPK,[4] PTBP1,[4] and HNRNPL.[4]

References[edit]

  1. ^ Tommerup N, Leffers H (May 1997). "Assignment of human KH-box-containing genes by in situ hybridization: HNRNPK maps to 9q21.32-q21.33, PCBP1 to 2p12-p13, and PCBP2 to 12q13.12-q13.13, distal to FRA12A". Genomics 32 (2): 297–8. doi:10.1006/geno.1996.0121. PMID 8833161. 
  2. ^ "Entrez Gene: PCBP2 poly(rC) binding protein 2". 
  3. ^ Braconi C, Valeri N, Kogure T, Gasparini P, Huang N, Nuovo GJ, Terracciano L, Croce CM, Patel T (2011-01-11). "Expression and functional role of a transcribed noncoding RNA with an ultraconserved element in hepatocellular carcinoma.". Proceedings of the National Academy of Sciences of the United States of America 108 (2): 786–91. doi:10.1073/pnas.1011098108. PMC 3021052. PMID 21187392. Retrieved 17 August 2011. 
  4. ^ a b c Kim JH, Hahm B, Kim YK, Choi M, Jang SK (May 2000). "Protein-protein interaction among hnRNPs shuttling between nucleus and cytoplasm". J. Mol. Biol. 298 (3): 395–405. doi:10.1006/jmbi.2000.3687. PMID 10772858. 

Further reading[edit]