PCDH12

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PCDH12
Identifiers
Aliases PCDH12, VE-cadherin-2, VECAD2, protocadherin 12
External IDs MGI: 1855700 HomoloGene: 9574 GeneCards: PCDH12
RNA expression pattern
PBB GE PCDH12 219656 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016580

NM_017378

RefSeq (protein)

NP_057664

NP_059074.2
NP_059074

Location (UCSC) Chr 5: 141.94 – 141.97 Mb Chr 18: 38.27 – 38.28 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Protocadherin-12 is a protein that in humans is encoded by the PCDH12 gene.[3][4][5]

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein consists of an extracellular domain containing 6 cadherin repeats, a transmembrane domain and a cytoplasmic tail that differs from those of the classical cadherins. The gene localizes to the region on chromosome 5 where the protocadherin gene clusters reside. The exon organization of this transcript is similar to that of the gene cluster transcripts, notably the first large exon, but no significant sequence homology exists. The function of this cellular adhesion protein is undetermined but mouse protocadherin 12 does not bind catenins and appears to have no effect on cell migration or growth.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Wu Q, Maniatis T (Apr 2000). "Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes". Proc Natl Acad Sci U S A. 97 (7): 3124–9. doi:10.1073/pnas.060027397. PMC 16203Freely accessible. PMID 10716726. 
  4. ^ Wu Q, Maniatis T (Jul 1999). "A striking organization of a large family of human neural cadherin-like cell adhesion genes". Cell. 97 (6): 779–90. doi:10.1016/S0092-8674(00)80789-8. PMID 10380929. 
  5. ^ a b "Entrez Gene: PCDH12 protocadherin 12". 

Further reading[edit]