PCDH17

From Wikipedia, the free encyclopedia
Jump to: navigation, search
PCDH17
Identifiers
Aliases PCDH17, PCDH68, PCH68, protocadherin 17
External IDs MGI: 2684924 HomoloGene: 8700 GeneCards: PCDH17
RNA expression pattern
PBB GE PCDH17 205656 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001040429
NM_014459

NM_001013753

RefSeq (protein)

NP_001035519

n/a

Location (UCSC) Chr 13: 57.63 – 57.73 Mb Chr 14: 84.44 – 84.54 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Protocadherin-17 is a protein that in humans is encoded by the PCDH17 gene.[3][4]

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein contains six extracellular cadherin domains, a transmembrane domain, and a cytoplasmic tail differing from those of the classical cadherins. The encoded protein may play a role in the establishment and function of specific cell-cell connections in the brain.[4] PCDH17 promoter methylation is found to be closely associated with bladder cancer malignancy [5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Nollet F, Kools P, van Roy F (Jul 2000). "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members". J Mol Biol. 299 (3): 551–72. doi:10.1006/jmbi.2000.3777. PMID 10835267. 
  4. ^ a b "Entrez Gene: PCDH17 protocadherin 17". 
  5. ^ Wang XB (Apr 2014). "Protocadherin 17 promoter methylation in tumour tissue from patients with bladder transitional cell carcinoma.". J Int Med Res. 42: 292–9. doi:10.1177/0300060513504364. PMID 24567353. 

Further reading[edit]