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Protein PCDHA4 PDB 1wuz.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases PCDHA4, CNR1, CNRN1, CRNR1, PCDH-ALPHA4, protocadherin alpha 4
External IDs MGI: 1298406 HomoloGene: 130626 GeneCards: 56144
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 5: 140.81 – 141.01 Mb Chr 18: 36.95 – 37.19 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Protocadherin alpha-4 is a protein that in humans is encoded by the PCDHA4 gene.[1][2][3]

This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.[3]


  1. ^ Wu Q, Maniatis T (Jul 1999). "A striking organization of a large family of human neural cadherin-like cell adhesion genes". Cell 97 (6): 779–90. doi:10.1016/S0092-8674(00)80789-8. PMID 10380929. 
  2. ^ Sugino H, Hamada S, Yasuda R, Tuji A, Matsuda Y, Fujita M, Yagi T (Apr 2000). "Genomic organization of the family of CNR cadherin genes in mice and humans". Genomics 63 (1): 75–87. doi:10.1006/geno.1999.6066. PMID 10662547. 
  3. ^ a b "Entrez Gene: PCDHA4 protocadherin alpha 4". 

Further reading[edit]