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Aliases PCDHB11, ME2, PCDH-BETA11, protocadherin beta 11
External IDs MGI: 2136759 HomoloGene: 134302 GeneCards: PCDHB11
RNA expression pattern
PBB GE PCDHB11 208504 x at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 5: 141.2 – 141.2 Mb Chr 18: 37.51 – 37.52 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Protocadherin beta-11 is a protein that in humans is encoded by the PCDHB11 gene.[3][4]

This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections.[4]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Wu Q, Maniatis T (Jul 1999). "A striking organization of a large family of human neural cadherin-like cell adhesion genes". Cell. 97 (6): 779–90. doi:10.1016/S0092-8674(00)80789-8. PMID 10380929. 
  4. ^ a b "Entrez Gene: PCDHB11 protocadherin beta 11". 

Further reading[edit]