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Aliases PCDHB16, ME1, PCDH-BETA16, PCDH3X, PCDHB8a, protocadherin beta 16
External IDs MGI: 2136754 HomoloGene: 81881 GeneCards: PCDHB16
RNA expression pattern
PBB GE PCDHB13 221450 x at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 5: 141.18 – 141.19 Mb Chr 18: 37.48 – 37.49 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Protocadherin beta-16 is a protein that in humans is encoded by the PCDHB16 gene.[3][4][5]

This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections.[5]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Wu Q, Zhang T, Cheng JF, Kim Y, Grimwood J, Schmutz J, Dickson M, Noonan JP, Zhang MQ, Myers RM, Maniatis T (Mar 2001). "Comparative DNA Sequence Analysis of Mouse and Human Protocadherin Gene Clusters". Genome Res. 11 (3): 389–404. doi:10.1101/gr.167301. PMC 311048Freely accessible. PMID 11230163. 
  4. ^ Vanhalst K, Kools P, Vanden Eynde E, van Roy F (Apr 2001). "The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number". FEBS Lett. 495 (1–2): 120–5. doi:10.1016/S0014-5793(01)02372-9. PMID 11322959. 
  5. ^ a b "Entrez Gene: PCDHB16 protocadherin beta 16". 

Further reading[edit]