PCDHGA12

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PCDHGA12
Identifiers
Aliases PCDHGA12, CDH21, FIB3, PCDH-GAMMA-A12, protocadherin gamma subfamily A, 12
External IDs MGI: 1935229 HomoloGene: 134588 GeneCards: PCDHGA12
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_032094
NM_003735

NM_033595

RefSeq (protein)

NP_003726
NP_115265

n/a

Location (UCSC) Chr 5: 141.43 – 141.51 Mb Chr 18: 37.77 – 37.84 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Protocadherin gamma-A12 is a protein that in humans is encoded by the PCDHGA12 gene.[3][4]

This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Wu Q, Maniatis T (Jul 1999). "A striking organization of a large family of human neural cadherin-like cell adhesion genes". Cell. 97 (6): 779–90. doi:10.1016/S0092-8674(00)80789-8. PMID 10380929. 
  4. ^ a b "Entrez Gene: PCDHGA12 protocadherin gamma subfamily A, 12". 

Further reading[edit]