PCGF2

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PCGF2
Protein PCGF2 PDB 2h0d.png
Identifiers
Aliases PCGF2, MEL-18, RNF110, ZNF144, polycomb group ring finger 2
External IDs MGI: 99161 HomoloGene: 5174 GeneCards: PCGF2
RNA expression pattern
PBB GE PCGF2 213551 x at fs.png

PBB GE PCGF2 203793 x at fs.png

PBB GE PCGF2 203792 x at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007144

NM_001163307
NM_001163308
NM_009545

RefSeq (protein)

NP_009075

Location (UCSC) Chr 17: 38.73 – 38.75 Mb Chr 11: 97.69 – 97.7 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Polycomb group RING finger protein 2 is a protein that in humans is encoded by the PCGF2 gene.[3][4]

Function[edit]

The protein encoded by this gene contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Ishida A, Asano H, Hasegawa M, Koseki H, Ono T, Yoshida MC, Taniguchi M, Kanno M (July 1993). "Cloning and chromosome mapping of the human Mel-18 gene which encodes a DNA-binding protein with a new 'RING-finger' motif". Gene. 129 (2): 249–55. doi:10.1016/0378-1119(93)90275-8. PMID 8325509. 
  4. ^ a b "Entrez Gene: PCGF2 polycomb group ring finger 2". 

Further reading[edit]