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Programmed cell death 4 (neoplastic transformation inhibitor)
Protein PDCD4 PDB 2ggf.png
PDB rendering based on 2ggf.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PDCD4 ; H731
External IDs OMIM608610 MGI107490 HomoloGene7879 ChEMBL: 1781868 GeneCards: PDCD4 Gene
RNA expression pattern
PBB GE PDCD4 202731 at tn.png
PBB GE PDCD4 202730 s at tn.png
PBB GE PDCD4 212593 s at tn.png
More reference expression data
Species Human Mouse
Entrez 27250 18569
Ensembl ENSG00000150593 ENSMUSG00000024975
UniProt Q53EL6 Q61823
RefSeq (mRNA) NM_001199492 NM_001168491
RefSeq (protein) NP_001186421 NP_001161963
Location (UCSC) Chr 10:
112.63 – 112.66 Mb
Chr 19:
53.89 – 53.93 Mb
PubMed search [1] [2]

Programmed cell death protein 4 is a protein that in humans is encoded by the PDCD4 gene.[1][2] It is one of the targets of an oncomiR, MIRN21.[3]


This gene encodes a protein localized to the nucleus in proliferating cells. Expression of this gene is modulated by cytokines in natural killer and T cells. The gene product is thought to play a role in apoptosis but the specific role has not yet been determined. Two transcripts encoding different isoforms have been identified.[2]


PDCD4 has been shown to interact with RPS13[4] and Ribosomal protein L5.[4]


  1. ^ Azzoni L, Zatsepina O, Abebe B, Bennett IM, Kanakaraj P, Perussia B (1998). "Differential transcriptional regulation of CD161 and a novel gene, 197/15a, by IL-2, IL-15, and IL-12 in NK and T cells". Journal of immunology 161 (7): 3493–500. PMID 9759869. 
  2. ^ a b EntrezGene 27250
  3. ^ Frankel LB, Christoffersen NR, Jacobsen A, Lindow M, Krogh A, Lund AH (2008). "Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells". The Journal of Biological Chemistry 283 (2): 1026–33. doi:10.1074/jbc.M707224200. PMID 17991735. 
  4. ^ a b Kang MJ, Ahn HS, Lee JY, Matsuhashi S, Park WY (2002). "Up-regulation of PDCD4 in senescent human diploid fibroblasts". Biochemical and Biophysical Research Communications 293 (1): 617–21. doi:10.1016/S0006-291X(02)00264-4. PMID 12054647. 

Further reading[edit]