PDCD6

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PDCD6
Protein PDCD6 PDB 1hqv.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PDCD6, ALG-2, PEF1B, ALG2, programmed cell death 6
External IDs MGI: 109283 HomoloGene: 7880 GeneCards: PDCD6
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001267556
NM_001267557
NM_001267558
NM_001267559
NM_013232

NM_011051

RefSeq (protein)

NP_001254485
NP_001254486
NP_001254487
NP_001254488
NP_037364

NP_035181.1
NP_035181

Location (UCSC) Chr 5: 0.27 – 0.35 Mb Chr 13: 74.3 – 74.32 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Programmed cell death protein 6 is a protein that in humans is encoded by the PDCD6 gene.[3]

This gene encodes a calcium-binding protein belonging to the penta-EF-hand protein family. Calcium binding is important for homodimerization and for conformational changes required for binding to other protein partners. This gene product participates in T cell receptor-, Fas-, and glucocorticoid-induced programmed cell death. In mice deficient for this gene product, however, apoptosis was not blocked suggesting this gene product is functionally redundant.[4]

Interactions[edit]

PDCD6 has been shown to interact with ASK1,[5] PDCD6IP,[6][7] Fas receptor,[8] ANXA11[7] and PEF1.[9]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Vito P, Lacana E, D'Adamio L (February 1996). "Interfering with apoptosis: Ca(2+)-binding protein ALG-2 and Alzheimer's disease gene ALG-3". Science. 271 (5248): 521–5. doi:10.1126/science.271.5248.521. PMID 8560270. 
  4. ^ "Entrez Gene: PDCD6 programmed cell death 6". 
  5. ^ Hwang, In-Sik; Jung Yong-Sam; Kim Eunhee (October 2002). "Interaction of ALG-2 with ASK1 influences ASK1 localization and subsequent JNK activation". FEBS Lett. Netherlands. 529 (2–3): 183–7. doi:10.1016/S0014-5793(02)03329-X. ISSN 0014-5793. PMID 12372597. 
  6. ^ Vito, P; Pellegrini L; Guiet C; D'Adamio L (January 1999). "Cloning of AIP1, a novel protein that associates with the apoptosis-linked gene ALG-2 in a Ca2+-dependent reaction". J. Biol. Chem. UNITED STATES. 274 (3): 1533–40. doi:10.1074/jbc.274.3.1533. ISSN 0021-9258. PMID 9880530. 
  7. ^ a b Satoh, Hirokazu; Shibata Hideki; Nakano Yoshimi; Kitaura Yasuyuki; Maki Masatoshi (March 2002). "ALG-2 interacts with the amino-terminal domain of annexin XI in a Ca(2+)-dependent manner". Biochem. Biophys. Res. Commun. United States. 291 (5): 1166–72. doi:10.1006/bbrc.2002.6600. ISSN 0006-291X. PMID 11883939. 
  8. ^ Jung, Y S; Kim K S; Kim K D; Lim J S; Kim J W; Kim E (October 2001). "Apoptosis-linked gene 2 binds to the death domain of Fas and dissociates from Fas during Fas-mediated apoptosis in Jurkat cells". Biochem. Biophys. Res. Commun. United States. 288 (2): 420–6. doi:10.1006/bbrc.2001.5769. ISSN 0006-291X. PMID 11606059. 
  9. ^ Kitaura, Y; Matsumoto S; Satoh H; Hitomi K; Maki M (April 2001). "Peflin and ALG-2, members of the penta-EF-hand protein family, form a heterodimer that dissociates in a Ca2+-dependent manner". J. Biol. Chem. United States. 276 (17): 14053–8. doi:10.1074/jbc.M008649200. ISSN 0021-9258. PMID 11278427. 

Further reading[edit]

External links[edit]