PDE11A

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PDE11A
Identifiers
Aliases PDE11A, PPNAD2, phosphodiesterase 11A
External IDs MGI: 3036251 HomoloGene: 56763 GeneCards: PDE11A
Targeted by Drug
tadalafil[1]
RNA expression pattern
PBB GE PDE11A 221110 x at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016953
NM_001077196
NM_001077197
NM_001077358

NM_001081033

RefSeq (protein)

NP_001070664
NP_001070665
NP_001070826
NP_058649

NP_001074502.1
NP_001074502

Location (UCSC) Chr 2: 177.62 – 178.11 Mb Chr 2: 75.99 – 76.34 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A is an enzyme that in humans is encoded by the PDE11A gene.[4][5]

The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene.[5]

Inhibitors[edit]

References[edit]

  1. ^ "Drugs that physically interact with Phosphodiesterase 11A view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Fawcett L, Baxendale R, Stacey P, McGrouther C, Harrow I, Soderling S, Hetman J, Beavo JA, Phillips SC (Apr 2000). "Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A". Proc Natl Acad Sci U S A. 97 (7): 3702–7. doi:10.1073/pnas.050585197. PMC 16303Freely accessible. PMID 10725373. 
  5. ^ a b "Entrez Gene: PDE11A phosphodiesterase 11A". 
  6. ^ Ceyhan O, Birsoy K, Hoffman CS (2012). "Identification of biologically active PDE11-selective inhibitors using a yeast-based high-throughput screen". Chem. Biol. 19 (1): 155–63. doi:10.1016/j.chembiol.2011.12.010. PMID 22284362. 

Further reading[edit]