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Phosphodiesterase 4D, cAMP-specific
Protein PDE4D PDB 1mkd.png
PDB rendering based on 1mkd.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM600129 MGI99555 HomoloGene129755 ChEMBL: 288 GeneCards: PDE4D Gene
EC number
RNA expression pattern
PBB GE PDE4D 210837 s at tn.png
PBB GE PDE4D 210836 x at tn.png
PBB GE PDE4D 211840 s at tn.png
More reference expression data
Species Human Mouse
Entrez 5144 238871
Ensembl ENSG00000113448 ENSMUSG00000021699
UniProt Q08499 Q01063
RefSeq (mRNA) NM_001104631 NM_011056
RefSeq (protein) NP_001098101 NP_035186
Location (UCSC) Chr 5:
58.97 – 60.52 Mb
Chr 13:
108.45 – 109.95 Mb
PubMed search [1] [2]

cAMP-specific 3',5'-cyclic phosphodiesterase 4D is an enzyme that in humans is encoded by the PDE4D gene.


The PDE4D gene is complex and has at least 9 different isoforms that encode functional proteins. These proteins degrade the second messenger cAMP, which is a key signal transduction molecule in multiple cell types, including vascular cells (Dominiczak and McBride, 2003).[supplied by OMIM][1]


PDE4D has been shown to interact with myomegalin[2] and GNB2L1.[3][4]

Clinical relevance[edit]

Mutations in this gene have been associated to cases of acrodysostosis.[5]

This is the subtype of PDE4 that appears to be involved in the emetic and antidepressant effects of PDE4 inhibitors.[6]


  1. ^ "Entrez Gene: PDE4D phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)". 
  2. ^ Verde I, Pahlke G, Salanova M, Zhang G, Wang S, Coletti D, Onuffer J, Jin SL, Conti M (Apr 2001). "Myomegalin is a novel protein of the golgi/centrosome that interacts with a cyclic nucleotide phosphodiesterase". The Journal of Biological Chemistry 276 (14): 11189–98. doi:10.1074/jbc.M006546200. PMID 11134006. 
  3. ^ Yarwood SJ, Steele MR, Scotland G, Houslay MD, Bolger GB (May 1999). "The RACK1 signaling scaffold protein selectively interacts with the cAMP-specific phosphodiesterase PDE4D5 isoform". The Journal of Biological Chemistry 274 (21): 14909–17. doi:10.1074/jbc.274.21.14909. PMID 10329691. 
  4. ^ Steele MR, McCahill A, Thompson DS, MacKenzie C, Isaacs NW, Houslay MD, Bolger GB (Jul 2001). "Identification of a surface on the beta-propeller protein RACK1 that interacts with the cAMP-specific phosphodiesterase PDE4D5". Cellular Signalling 13 (7): 507–13. doi:10.1016/S0898-6568(01)00167-X. PMID 11516626. 
  5. ^ Michot C, Le Goff C, Goldenberg A, Abhyankar A, Klein C, Kinning E, Guerrot AM, Flahaut P, Duncombe A, Baujat G, Lyonnet S, Thalassinos C, Nitschke P, Casanova JL, Le Merrer M, Munnich A, Cormier-Daire V (Apr 2012). "Exome sequencing identifies PDE4D mutations as another cause of acrodysostosis". American Journal of Human Genetics 90 (4): 740–5. doi:10.1016/j.ajhg.2012.03.003. PMID 22464250. 
  6. ^ Zhang HT (2009). "Cyclic AMP-specific phosphodiesterase-4 as a target for the development of antidepressant drugs". Current Pharmaceutical Design 15 (14): 1688–98. doi:10.2174/138161209788168092. PMID 19442182. 

Further reading[edit]