3',5'-cyclic-AMP phosphodiesterase

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3',5'-cyclic-AMP phosphodiesterase
EC number3.1.4.53
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum

3',5'-cyclic-AMP phosphodiesterase (EC, cAMP-specific phosphodiesterase, cAMP-specific PDE, PDE1, PDE2A, PDE2B, PDE4, PDE7, PDE8, PDEB1, PDEB2) is an enzyme with systematic name 3',5'-cyclic-AMP 5'-nucleotidohydrolase.[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction

adenosine 3',5'-cyclic phosphate + H2O AMP

This enzyme requires Mg2+ or Mn2+ for activity.


  1. ^ Alonso GD, Schoijet AC, Torres HN, Flawiá MM (January 2006). "TcPDE4, a novel membrane-associated cAMP-specific phosphodiesterase from Trypanosoma cruzi". Molecular and Biochemical Parasitology. 145 (1): 40–9. doi:10.1016/j.molbiopara.2005.09.005. PMID 16225937.
  2. ^ Bader S, Kortholt A, Snippe H, Van Haastert PJ (July 2006). "DdPDE4, a novel cAMP-specific phosphodiesterase at the surface of dictyostelium cells". The Journal of Biological Chemistry. 281 (29): 20018–26. doi:10.1074/jbc.M600040200. PMID 16644729.
  3. ^ Rascón A, Soderling SH, Schaefer JB, Beavo JA (April 2002). "Cloning and characterization of a cAMP-specific phosphodiesterase (TbPDE2B) from Trypanosoma brucei". Proceedings of the National Academy of Sciences of the United States of America. 99 (7): 4714–9. Bibcode:2002PNAS...99.4714R. doi:10.1073/pnas.002031599. PMC 123713. PMID 11930017.
  4. ^ Johner A, Kunz S, Linder M, Shakur Y, Seebeck T (March 2006). "Cyclic nucleotide specific phosphodiesterases of Leishmania major". BMC Microbiology. 6: 25. doi:10.1186/1471-2180-6-25. PMC 1431542. PMID 16522215.
  5. ^ Lugnier C, Keravis T, Le Bec A, Pauvert O, Proteau S, Rousseau E (November 1999). "Characterization of cyclic nucleotide phosphodiesterase isoforms associated to isolated cardiac nuclei". Biochimica et Biophysica Acta (BBA) - General Subjects. 1472 (3): 431–46. doi:10.1016/S0304-4165(99)00145-2. PMID 10564757.
  6. ^ Imamura R, Yamanaka K, Ogura T, Hiraga S, Fujita N, Ishihama A, Niki H (October 1996). "Identification of the cpdA gene encoding cyclic 3',5'-adenosine monophosphate phosphodiesterase in Escherichia coli". The Journal of Biological Chemistry. 271 (41): 25423–9. doi:10.1074/jbc.271.41.25423. PMID 8810311.

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