PDE8A

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PDE8A
Protein PDE8A PDB 1LHQ.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PDE8A, HsT19550, phosphodiesterase 8A
External IDs MGI: 1277116 HomoloGene: 1957 GeneCards: PDE8A
Targeted by Drug
dipyridamole[1]
RNA expression pattern
PBB GE PDE8A 212522 at fs.png

PBB GE PDE8A 212521 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_008803

RefSeq (protein)

NP_001230066
NP_002596
NP_775656

NP_032829.1
NP_032829

Location (UCSC) Chr 15: 84.98 – 85.14 Mb Chr 7: 81.21 – 81.33 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A is an enzyme that in humans is encoded by the PDE8A gene.[4][5] Work by Sebastiaan Bol et al. showed that 5 different transcript variants and their corresponding isoforms are expressed in human macrophages, and suggests that this protein may be required by HIV-1 for its replication.[6]


References[edit]

  1. ^ "Drugs that physically interact with Phosphodiesterase 8A view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Fisher DA, Smith JF, Pillar JS, St Denis SH, Cheng JB (Jul 1998). "Isolation and characterization of PDE8A, a novel human cAMP-specific phosphodiesterase". Biochem Biophys Res Commun. 246 (3): 570–7. doi:10.1006/bbrc.1998.8684. PMID 9618252. 
  5. ^ "Entrez Gene: PDE8A phosphodiesterase 8A". 
  6. ^ Bol SM, Booiman T, Bunnik EM, Moerland PD, van Dort K, Strauss JF III, Sieberer M, Schuitemaker H, Kootstra NA, van 't Wout AB (Sep 2011). "Polymorphism in HIV-1 dependency factor PDE8A affects mRNA level and HIV-1 replication in primary macrophages". Virology. 420 (1): 32–42. doi:10.1016/j.virol.2011.08.013. PMID 21920574. 

Further reading[edit]