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Phosphodiesterase 8A
Protein PDE8A PDB 1LHQ.png
Rendering based on PDB 1LHQ​.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PDE8A ; HsT19550
External IDs OMIM602972 MGI1277116 HomoloGene1957 ChEMBL: 4640 GeneCards: PDE8A Gene
EC number
RNA expression pattern
PBB GE PDE8A 212521 s at tn.png
PBB GE PDE8A 212522 at tn.png
More reference expression data
Species Human Mouse
Entrez 5151 18584
Ensembl ENSG00000073417 ENSMUSG00000025584
UniProt O60658 O88502
RefSeq (mRNA) NM_001243137 NM_008803
RefSeq (protein) NP_001230066 NP_032829
Location (UCSC) Chr 15:
84.98 – 85.14 Mb
Chr 7:
81.21 – 81.33 Mb
PubMed search [1] [2]

High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A is an enzyme that in humans is encoded by the PDE8A gene.[1][2] Work by Sebastiaan Bol et al. showed that 5 different transcript variants and their corresponding isoforms are expressed in human macrophages, and suggests that this protein may be required by HIV-1 for its replication.[3]


  1. ^ Fisher DA, Smith JF, Pillar JS, St Denis SH, Cheng JB (Jul 1998). "Isolation and characterization of PDE8A, a novel human cAMP-specific phosphodiesterase". Biochem Biophys Res Commun 246 (3): 570–7. doi:10.1006/bbrc.1998.8684. PMID 9618252. 
  2. ^ "Entrez Gene: PDE8A phosphodiesterase 8A". 
  3. ^ Bol SM, Booiman T, Bunnik EM, Moerland PD, van Dort K, Strauss JF 3rd, Sieberer M, Schuitemaker H, Kootstra NA, van 't Wout AB (Sep 2011). "Polymorphism in HIV-1 dependency factor PDE8A affects mRNA level and HIV-1 replication in primary macrophages". Virology 420 (1): 32–42. doi:10.1016/j.virol.2011.08.013. PMID 21920574. 

Further reading[edit]