PDGFA

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PDGFA
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPDGFA, PDGF-A, PDGF1, platelet derived growth factor subunit A
External IDsOMIM: 173430 MGI: 97527 HomoloGene: 32055 GeneCards: PDGFA
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for PDGFA
Genomic location for PDGFA
Band7p22.3Start497,258 bp[1]
End520,296 bp[1]
RNA expression pattern
PBB GE PDGFA 216867 s at fs.png

PBB GE PDGFA 205463 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002607
NM_033023

NM_008808
NM_001363271

RefSeq (protein)

NP_002598
NP_148983

NP_032834
NP_001350200

Location (UCSC)Chr 7: 0.5 – 0.52 MbChr 5: 138.98 – 139 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Platelet-derived growth factor subunit A is a protein that in humans is encoded by the PDGFA gene.[5][6]

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer or as a heterodimer with the platelet-derived growth factor beta polypeptide, where the dimers are connected by disulfide bonds. Studies using knockout mice have shown cellular defects in oligodendrocytes, alveolar smooth muscle cells, and Leydig cells in the testis; knockout mice die either as embryos or shortly after birth. Two splice variants have been identified for this gene.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000197461 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025856 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Stenman G, Rorsman F, Huebner K, Betsholtz C (Sep 1992). "The human platelet-derived growth factor alpha chain (PDGFA) gene maps to chromosome 7p22". Cytogenet Cell Genet. 60 (3–4): 206–7. doi:10.1159/000133337. PMID 1505216.
  6. ^ Matsui T, Heidaran M, Miki T, Popescu N, La Rochelle W, Kraus M, Pierce J, Aaronson S (Mar 1989). "Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes". Science. 243 (4892): 800–4. doi:10.1126/science.2536956. PMID 2536956.
  7. ^ "Entrez Gene: PDGFA platelet-derived growth factor alpha polypeptide".

Further reading[edit]