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Protein PDLIM5 PDB 1wf7.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases PDLIM5, ENH, ENH1, LIM, L9, PDZ and LIM domain 5
External IDs MGI: 1927489 HomoloGene: 21289 GeneCards: PDLIM5
Genetically Related Diseases
prostate cancer[1]
RNA expression pattern
PBB GE PDLIM5 203242 s at fs.png

PBB GE PDLIM5 203243 s at fs.png

PBB GE PDLIM5 211681 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC) Chr 4: 94.45 – 94.67 Mb Chr 3: 142.24 – 142.4 Mb
PubMed search [2] [3]
View/Edit Human View/Edit Mouse

PDZ and LIM domain protein 5 is a protein that in humans is encoded by the PDLIM5 gene.[4][5]

The protein encoded by this gene is a LIM domain protein. LIM domains are cysteine-rich double zinc fingers composed of 50 to 60 amino acids that are involved in protein-protein interactions. LIM domain-containing proteins are scaffolds for the formation of multiprotein complexes. The proteins are involved in cytoskeleton organization, cell lineage specification, organ development, and oncogenesis. The encoded protein is also a member of the Enigma class of proteins, a family of proteins that possess a 100-amino acid PDZ domain in the N terminus and 1 to 3 LIM domains in the C terminus. Multiple transcript variants encoding different isoforms have been found for this gene, although not all of them have been fully characterized.[5]


PDLIM5 has been shown to interact with PRKCB1.[6]


  1. ^ "Diseases that are genetically associated with PDLIM5 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Wu M, Li Y, Ji C, Xu J, Zheng H, Zou X, Gu S, Lou Y, Xie Y, Mao Y (September 2004). "Cloning and identification of a novel human gene PDLIM5, a homolog of AD-associated neuronal thread protein (AD7c-NTP)". DNA Seq. 15 (2): 144–7. doi:10.1080/10425170310001656756. PMID 15346770. 
  5. ^ a b "Entrez Gene: PDLIM5 PDZ and LIM domain 5". 
  6. ^ Kuroda, S; Tokunaga C; Kiyohara Y; Higuchi O; Konishi H; Mizuno K; Gill G N; Kikkawa U (December 1996). "Protein-protein interaction of zinc finger LIM domains with protein kinase C". J. Biol. Chem. UNITED STATES. 271 (49): 31029–32. doi:10.1074/jbc.271.49.31029. ISSN 0021-9258. PMID 8940095. 

Further reading[edit]